IL-4 antibody (PE)

Catalog No. ABIN1107850

Product Details anti-IL-4 Antibody (PE)

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-4 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: The antibody detects human Interleukin 4, which is a 14 kDa molecular weight glycoprotein. Other species not tested.

Purification: Affinity chromatography

Clone: 8F-12

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.

Target Details for IL-4

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Alternative Name: Interleukin-4 / IL4 (IL4 Products)

Synonyms: IL4 antibody, IL-4 antibody, BCGF-1 antibody, BCGF1 antibody, BSF-1 antibody, BSF1 antibody, Il-4 antibody, Il4e12 antibody, IL2 antibody, interleukin 4 antibody, IL4 antibody, Il4 antibody

Background: The immune system reacts to a pathogen by activation of balanced network of the humoral and cellular immune responses. Subsequently the activated condition of the immune system will, after the elimination of the pathogen, be down-regulated to a balanced situation again. Control of the immune response requires efficient communication between the different cells involved in this response. This interaction is provided by cell/cell contact and by a complex array of mediators. Among these mediators cytokines, soluble factors produced by these cells, play an important role. Cytokines can act on other cells locally or distantly, but can be even auto regulating. Cytokines can behave stimulatory or inhibitory, or can even perform both activities, depending on the (pre)activation stage of the target cell. (3, 4) Interleukine 4 (IL-4) is a cytokine expressed by activated T cells, mast cells and bone marrow stromal cells. Originally, IL-4 was referred to as the B cell differentiation factor, B cell growth factor 1 or B cell stimulatory factor 1. The function of IL-4 is pleiotropic, i.e. stimulation, proliferation induction, and modulation of target cell functions. These target cells include B cells, but also T cells, NK and LAK cells, as well as antigen-processing cells like monocytes and macrophages.Synonyms: B-cell stimulatory factor 1, BSF1, Binetrakin, IL-4, Lymphocyte stimulatory factor 1, Pitrakinra

Gene ID: 3565

NCBI Accession: NP_000580

UniProt: P05112

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation