JAM3 antibody

Catalog No. ABIN1107891

Product Details anti-JAM3 Antibody

Target: JAM3 (Junctional Adhesion Molecule 3 (JAM3))

Reactivity: Human, Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This JAM3 antibody is un-conjugated

Application: Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Protein G

Clone: 19H36

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for JAM3

Target: JAM3 (Junctional Adhesion Molecule 3 (JAM3))

Alternative Name: JAM3 / JAM-C (JAM3 Products)

Synonyms: JAM3 antibody, jam3 antibody, sr:nyz155 antibody, wu:fb30h11 antibody, wu:fc08c06 antibody, wu:fc13e04 antibody, wu:fc25g11 antibody, jamc.2 antibody, 1110002N23Rik antibody, JAM-3 antibody, JAM-C antibody, Jcam3 antibody, JAM-2 antibody, JAMC antibody, junctional adhesion molecule 3 antibody, junctional adhesion molecule 3b antibody, junctional adhesion molecule 3a antibody, junction adhesion molecule 3 antibody, JAM3 antibody, jam3b antibody, jam3a antibody, Jam3 antibody

Background: Junctional adhesion molecule-C (JAM-C) also known as JAM-2 is a 45 kD cell adhesion molecule (CAM). JAM-C is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM-C belongs together with JAM-A (JAM or JAM-1) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-C is potentially involved in the junctional sealing of the vascular endothelium, in particular of high endothelial venules (HEV). In adult murine tissue JAM-C expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney.Synonyms: Junctional adhesion molecule 3, Junctional adhesion molecule C

Gene ID: 83964

NCBI Accession: NP_075766

UniProt: Q9D8B7