JUP antibody
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- Target See all JUP Antibodies
- JUP (Junction Plakoglobin (JUP))
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Reactivity
- Human, Rat, Chicken
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This JUP antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- Recognizes Catenin Gamma (Plakoglobin). No cross reactivity with other proteins.
- Purification
- Affinity Chromatography
- Immunogen
- Recombinant Chicken plakoglobin.
- Clone
- CN-3
- Isotype
- IgG1
- Top Product
- Discover our top product JUP Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Reconstitution
- Restore with 1.2 % Sodium Acetate or neutral PBS.
- Concentration
- 0.1 mg/mL
- Buffer
- 1.2 % Sodium Acetate containing 2 mg BSA and 0.01 mg Sodium Azide as preservative.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- JUP (Junction Plakoglobin (JUP))
- Alternative Name
- Junction Plakoglobin (JUP Products)
- Synonyms
- ARVD12 antibody, CTNNG antibody, DP3 antibody, DPIII antibody, PDGB antibody, PKGB antibody, arvd12 antibody, ctnng antibody, dp3 antibody, dpiii antibody, pdgb antibody, pkgb antibody, plak antibody, D930025P04Rik antibody, PG antibody, cb80 antibody, danPG antibody, fb11b06 antibody, jup antibody, wu:fb11b06 antibody, junction plakoglobin antibody, junction plakoglobin L homeolog antibody, Junction plakoglobin antibody, junction plakoglobin a antibody, junction plakoglobin S homeolog antibody, JUP antibody, Jup antibody, jup antibody, jup.L antibody, Tsp_06656 antibody, plak antibody, jupa antibody, jup.S antibody
- Background
- Junction Plakoglobin (JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.Synonyms: CTNNG, Catenin gamma, DP3, Desmoplakin III, Desmoplakin-3, JUP
- Gene ID
- 3728
- NCBI Accession
- NP_002221
- UniProt
- P14923
- Pathways
- Cell-Cell Junction Organization, Maintenance of Protein Location
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