K(lysine) Acetyltransferase 5 (KAT5) antibody

Details for Product No. ABIN1107913
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Antigen
Synonyms
6121, CG6121, DmEG0007.7, Dmel/TIP60, Dmel\\CG6121, Dmel\\TIP60, EG0007.7, EG:EG0007.7, TIP60, dTIP60, dTip60, dmHAG405, im:6908768, wu:fb55b08, zgc:110752, ESA1, HTATIP, HTATIP1, PLIP, TIP, ZC2HC5, c ... show more
6121, CG6121, DmEG0007.7, Dmel/TIP60, Dmel\\CG6121, Dmel\\TIP60, EG0007.7, EG:EG0007.7, TIP60, dTIP60, dTip60, dmHAG405, im:6908768, wu:fb55b08, zgc:110752, ESA1, HTATIP, HTATIP1, PLIP, TIP, ZC2HC5, cPLA2, AI839539, CPLA2, Htatip, Htatip1, Tip55, Tip60 show less
Reactivity
Human
(152), (68), (49), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(132), (21)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(103), (86), (54), (19), (10), (9), (9), (6), (5), (5), (2), (1)
Pubmed 2 references available
Quantity 0.1 mL
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Clone 3F9
Isotype IgG2b
Specificity Recognizes HTATIP (HIV-1 Tat interacting protein TIP60, about 60 kDa).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name KAT5 (KAT5 Antibody Abstract)
Background HTATIP (HIV-1 Tat interacting protein TIP60, about 60 kDa) belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure. There are five major variants of histone H2A: canonical H2A (most abundant), H2A.X, MacroH2A, H2ABbd and H2A.Z. Histone H2A.Z, the most conserved variant across species, functions as both a positive and negative regulator of transcription and is important for chromosome stability. Several homologous protein complexes, such as SWR-C, TIP60 and SRCAP (mammals), have been shown to catalyze the ATP-dependent exchange of H2A.Z for H2A in the nucleosome. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.Synonyms: 60 kDa Tat-interactive protein, HIV-1 Tat interactive protein, HTATIP, Histone acetyltransferase HTATIP, Histone acetyltransferase KAT5, Lysine acetyltransferase 5, PLIP, TIP60, cPLA(2)-interacting protein
Molecular Weight 60 kDa
Gene ID 10524
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
anti-K(lysine) Acetyltransferase 5 (KAT5) antibody anti-K(lysine) Acetyltransferase 5 (KAT5) antibody
anti-K(lysine) Acetyltransferase 5 (KAT5) antibody (2) anti-K(lysine) Acetyltransferase 5 (KAT5) antibody (Image 2)
Background publications Jin, Cai, Li et al.: "In and out: histone variant exchange in chromatin." in: Trends in biochemical sciences, Vol. 30, Issue 12, pp. 680-7, 2005 (PubMed).

Mizuguchi, Shen, Landry et al.: "ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex." in: Science (New York, N.Y.), Vol. 303, Issue 5656, pp. 343-8, 2004 (PubMed).

Validation Images
Catalog No. ABIN1107913
390.50 $
Plus shipping costs $45.00
Quantity
Price
0.1 mL
390.50 $

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