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Kelch-Like 1 Protein antibody

Details for Product No. ABIN1107952, Supplier: Login to see
Antigen
Reactivity
Human
10
3
Host
Mouse
10
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
9
1
1
Supplier
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Clone 3A8
Isotype IgG1
Specificity Recognizes Kelch-like 1 protein (KLHL1)
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Background The mammalian Kelch like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin organizing proteins. Based on the presence of anti sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved in this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.Tissue specificity: Highly expressed in brain.Synonyms: KIAA1490, KLHL1
Molecular Weight 82 kDa
Gene ID 57626
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-Kelch-Like 1 Protein antibody (ABIN1107952) anti-Kelch-Like 1 Protein antibody
Immunofluorescence (IF) image for anti-Kelch-Like 1 Protein antibody (ABIN1107952) anti-Kelch-Like 1 Protein antibody (Image 2)
Background publications Barrios-Rodiles, Brown, Ozdamar et al.: "High-throughput mapping of a dynamic signaling network in mammalian cells." in: Science (New York, N.Y.), Vol. 307, Issue 5715, pp. 1621-5, 2005 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).