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Kelch-Like 22 (Drosophila) (KLHL22) antibody

Details for Product No. ABIN1107957, Supplier: Login to see
Antigen
  • 2610318I18Rik
  • Kelchl
  • KELCHL
  • RGD1306288
Reactivity
Human
40
16
16
Host
Mouse
29
11
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
29
19
11
8
4
4
1
Supplier
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Clone 7B10
Isotype IgG1
Specificity Recognizes Kelch-like protein 22 (KLHL22)
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name Kelch-Like Protein 22 (KLHL22 Antibody Abstract)
Background KLHL22 (kelch-like protein 22) is a 634 amino acid protein that is related to the Drosophilakelch protein, which is required to maintain Actin organization in ovarian ring canals. Mutations affecting Kelch function result in the failure of Kelch to associate with the ring canals and subsequent female sterility. Human KLHL22 protein contains six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. There are two isoforms of KLHL22 that are produced as a result of alternative splicing events.Synonyms: KLHL22
Molecular Weight 72 kDa
Gene ID 84861
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-Kelch-Like 22 (Drosophila) (KLHL22) antibody (ABIN1107957) anti-Kelch-Like 22 (Drosophila) (KLHL22) antibody
Immunofluorescence (IF) image for anti-Kelch-Like 22 (Drosophila) (KLHL22) antibody (ABIN1107957) anti-Kelch-Like 22 (Drosophila) (KLHL22) antibody (Image 2)
Background publications Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Maruyama, Sugano: "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides." in: Gene, Vol. 138, Issue 1-2, pp. 171-4, 1994 (PubMed).