LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody

Details for Product No. ABIN1108043, Supplier: Log in to see
Antigen
  • PINCH
  • PINCH-1
  • PINCH1
  • Pinch1
  • RGD1560732
  • LIMS3
  • LIMS3L
  • 2310016J22Rik
  • 4921524A02Rik
  • AI507642
  • AU021743
  • AW551584
  • C430041B13Rik
  • Lims1l
  • LIM and senescent cell antigen-like domains 1
  • LIMS1
  • Lims1
Reactivity
Human
53
32
32
5
4
4
4
4
4
3
3
2
2
2
Host
Mouse
43
11
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
38
19
13
13
9
8
6
5
3
1
1
Options
Supplier
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Supplier Product No.
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Clone 5G7
Isotype IgG1
Specificity This antibody reacts to PINCH.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name LIMS1 (LIMS1 Antibody Abstract)
Background The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.Synonyms: LIM and senescent cell antigen-like-containing domain protein 1, LIMS-1, PINCH, PINCH-1, PINCH1, Particularly interesting new Cys-His protein 1, Renal carcinoma antigen NY-REN-48
Molecular Weight 37 kDa
Gene ID 3987
Research Area Cancer, Angiogenesis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Flow Cytometry (FACS) image for anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody (ABIN1108043) anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody
Immunofluorescence (IF) image for anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody (ABIN1108043) anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody (Image 2)
Western Blotting (WB) image for anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody (ABIN1108043) anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody (Image 3)
Western Blotting (WB) image for anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody (ABIN1108043) anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody (Image 4)
ELISA image for anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody (ABIN1108043) anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody (Image 5)
Background publications Yang, Wang, Hawkins, Chen, Vaynberg, Mao, Tu, Zuo, Wang, Wang, Wu, Tjandra, Qin: "Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase." in: The Journal of biological chemistry, Vol. 284, Issue 9, pp. 5836-44, 2009 (PubMed).

Chiswell, Zhang, Murphy, Boggon, Calderwood: "The structural basis of integrin-linked kinase-PINCH interactions." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 52, pp. 20677-82, 2008 (PubMed).

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