Lipocalin 2 antibody

Catalog No. ABIN1108051

Product Details anti-Lipocalin 2 Antibody

Target: Lipocalin 2 (LCN2)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lipocalin 2 antibody is un-conjugated

Application: Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: The monoclonal antibody 697 reacts with Human neutrophil lipocalin (HNL), also known as Human nGAL (25 kDa).

Purification: Protein G Chromatography

Clone: 697

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % Sodium Azide, 0.1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8 °C.

Target Details for Lipocalin 2

Target: Lipocalin 2 (LCN2)

Alternative Name: Lipocalin-2 (LCN2 Products)

Synonyms: LCN2 antibody, 24p3 antibody, MSFI antibody, NGAL antibody, AW212229 antibody, Sip24 antibody, lipocalin 2 antibody, LCN2 antibody, Lcn2 antibody

Background: Lipocalins are a widespread family of small, robust proteins that typically transport or store biological compounds which are either of low solubility or are chemically sensitive, including vitamins, steroids, odorants and metabolic products. The members of this lipocalins share a high similarity in their tertiary structures in spite of a low degree in amino-acid sequence identity: three highly conserved sequence motifs form a funnel-like beta barrel which encloses a hydrophobic pocket for the internal ligand binding. The human neutrophil lipocalin (HNL) is produced by neutrophil leukocytes and stored in intracellular specific granules. Neutrophil lipocalin is covalently linked to gelatinase B (MMP-9) and proMMP is stored in three forms: the monomeric form (92 kDa), the homodimer (220 kDa) and a heterodimer (125 kDa). During inflammation and neoplastic transformation the human neutrophil lipocalin (HNL) is produced in neutrophils and in epithelial cells. Furthermore neutrophil lipocalin is a superior means to distinguish acute bacterial and viral infections as well as it enables the determination of the neutrophil activation level.Synonyms: 25 kDa alpha-2-microglobulin-related subunit of MMP-9, HNL, LCN2, NGAL, Neutrophil Gelatinase-associated Lipocalin, Oncogene 24p3, p25

Gene ID: 3934

NCBI Accession: NP_005555

UniProt: P80188

Pathways: Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis