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MAP2K4 antibody (Mitogen-Activated Protein Kinase Kinase 4)

Details for Product anti-MAP2K4 Antibody No. ABIN1108124, Supplier: Login to see New
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Antigen
Synonyms
jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CG9738, CT27508, D-MKK4, DMKK4, Dmel\\CG9738, JNKK2, MAPKK4, MKK4, Mpk4, SEK1/MKK4, dMKK4, dMkk4, hep, CT38386, DmelCG12798, Sek ... show more
jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CG9738, CT27508, D-MKK4, DMKK4, Dmel\\CG9738, JNKK2, MAPKK4, MKK4, Mpk4, SEK1/MKK4, dMKK4, dMkk4, hep, CT38386, DmelCG12798, Sek1, 2, JNKK, Jnkk2, Mapkk7, Mek7, Mkk7, JNKK1, MEK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, Serk1, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4, ATMEK4, ATMKK4, F19C24.26, F19C24_26, MAP KINASE KINASE 4, mitogen-activated protein kinase kinase 4, MKK4A-l, map2k4, zgc:136500 show less
Alternatives
Reactivity
Human
(316), (146), (114), (8), (5), (4), (4), (4), (2), (2)
Host
Mouse
(291), (38)
Clonality (Clone)
Monoclonal ()
Conjugate
This MAP2K4 antibody is un-conjugated
(12), (12), (11), (8), (8), (8), (5), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(213), (147), (113), (66), (45), (21), (17), (15), (14), (11), (3), (3), (2)
Pubmed 3 references available
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Quantity 0.1 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Clone 2D10D8
Isotype IgM
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name MAP2K4 (MAP2K4 Antibody Abstract)
Background MAP2K4 (mitogen-activated protein kinase kinase 4), which is located on chromosome 17p11.2, with 399-amino acid protein (about 45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases.MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors. By phosphorylating MAP kinases such as JNK,MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation. Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis, and metastasis suppression.Synonyms: Dual specificity mitogen-activated protein kinase kinase 4, JNK-activating kinase 1, MAP Kinase Kinase 4, MAPKK4, MEK-4, MKK4, PRKMK4, SAPK/ERK kinase 1, SERK1, c-Jun N-terminal kinase kinase 1
Gene ID 6416
Pathways MAPK Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 0.03 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Immunohistochemistry (IHC) image for anti-MAP2K4 antibody (Mitogen-Activated Protein Kinase Kinase 4) (ABIN1108124) anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) antibody
Background publications Kim, Vander Griend, Yang et al.: "Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers." in: Cancer research, Vol. 61, Issue 7, pp. 2833-7, 2001 (PubMed).

Cuenda: "Mitogen-activated protein kinase kinase 4 (MKK4)." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 6, pp. 581-7, 2000 (PubMed).

Crews, Alessandrini, Erikson: "The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product." in: Science (New York, N.Y.), Vol. 258, Issue 5081, pp. 478-80, 1992 (PubMed).

Catalog No. ABIN1108124
$335.50
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