Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) antibody

Details for Product No. ABIN1108200
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Antigen
Synonyms 7420452D20Rik, ASK, ASK1, MAPKKK5, Mekk5, mitogen-activated protein kinase kinase kinase 5, MUD21.11, MUD21_11, MEKK5, MAP3K5
Reactivity
Human
(384), (137), (78), (1)
Host
Mouse
(374), (17)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(15), (15), (14), (8), (8), (8), (6), (6), (6), (6), (6), (6), (6), (6)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(290), (160), (138), (60), (60), (36), (22), (12), (10), (6), (6), (5), (3), (2), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mL
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Clone 2-00E-004
Isotype IgG1
Specificity This antibody reacts to MAP3K5.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name MEKK5 / ASK1 (MAP3K5 Antibody Abstract)
Background Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells, MAPKKK5 does not activate MAPK/ERK.Synonyms: Apoptosis signal-regulating kinase 1, MAP3K5, MAPK/ERK kinase kinase 5, MAPKKK5, Mitogen-activated protein kinase kinase kinase 5
Molecular Weight 55 kDa
Gene ID 4217
Pathways MAPK Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) antibody anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) antibody
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) antibody (2) anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) antibody (Image 2)
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) antibody (3) anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) antibody (Image 3)
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) antibody (4) anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) antibody (Image 4)
anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) antibody (5) anti-Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) antibody (Image 5)
Background publications Widenmaier, Ao, Kim et al.: "Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent ..." in: The Journal of biological chemistry, Vol. 284, Issue 44, pp. 30372-82, 2009 (PubMed).

Validation Images
Catalog No. ABIN1108200
423.50 $
Plus shipping costs $45.00
Quantity
Price
0.1 mL
423.50 $

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