Mesothelin antibody (MSLN) (PE)

Details for Product anti-MSLN Antibody No. ABIN1108213, Supplier: Log in to see
Antigen
  • MSLN
  • CEPR
  • CMKRL2
  • DRY12
  • FEG-1
  • GPCR-Br
  • GPER
  • GPR30
  • LERGU
  • LERGU2
  • LyGPR
  • 6330420K13Rik
  • Ceprl
  • Gper
  • Gpr30
  • MPF
  • SMRP
  • mesothelin
  • G protein-coupled estrogen receptor 1
  • mesothelin-like
  • MSLN
  • GPER1
  • Gper1
  • Msln
  • LOC100524016
Alternatives
anti-Mouse (Murine) Mesothelin antibody for ELISA
Reactivity
Mouse (Murine)
179
33
6
3
2
2
2
2
1
1
1
1
Host
Rat
116
52
25
15
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Mesothelin antibody is conjugated to PE
12
10
8
4
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
117
73
52
42
40
13
7
7
4
4
3
3
2
2
2
2
1
1
Options
Supplier
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Immunogen Murine hemangioblast-like cell lineLO
Clone 295D
Isotype IgG2a
Specificity This antibody reacts with Mesothelin.
Cross-Reactivity (Details) Species reactivity (tested):Mouse (LO). Does not work with human (Jurkat).
Purification Protein G agarose
Alternative Name Mesothelin (MSLN Antibody Abstract)
Background Mesothelin (MSLN) is a GPI-linked cell surface glycoprotein expressed in the mesothelial lining of the body cavities and in mullerian duct epithelium related cancer cells (ovarian, pancreatic cancer, mesothelioma). Both human and mouse mesothelin bind to ovarian cancer antigen CA125/MUC16 with high affinity, mediating cell attachment in vitro, suggesting that mesothelin may facilitate ovarian cancer metastasis.Synonyms: CAK1 antigen, MPF, MSLN, Pre-pro-megakaryocyte-potentiating factor
Gene ID 56047
NCBI Accession NP_061345
UniProt Q61468
Research Area Cancer
Pathways EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer PBS, 0.09 % Sodium Azide, 1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-Mesothelin antibody (MSLN)  (PE) (ABIN1108213) anti-Mesothelin (MSLN) antibody (PE)
Background publications Ho, Hassan, Zhang, Wang, Onda, Bera, Pastan: "Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 10, pp. 3814-20, 2005 (PubMed).

Rump, Morikawa, Tanaka, Minami, Umesaki, Takeuchi, Miyajima: "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion." in: The Journal of biological chemistry, Vol. 279, Issue 10, pp. 9190-8, 2004 (PubMed).

Nakayama, Hara, Hibi, Hirano, Miyajima: "A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth." in: The Journal of biological chemistry, Vol. 274, Issue 35, pp. 24766-72, 1999 (PubMed).

Kojima, Oh-eda, Hattori, Taniguchi, Tamura, Ochi, Yamaguchi: "Molecular cloning and expression of megakaryocyte potentiating factor cDNA." in: The Journal of biological chemistry, Vol. 270, Issue 37, pp. 21984-90, 1995 (PubMed).