MIER1 antibody (Middle Region)

Catalog No. ABIN1108246

Product Details anti-MIER1 Antibody

Target: MIER1 (Mesoderm Induction Early Response 1 (MIER1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Cow, Rabbit, Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MIER1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RRTGDEKGVE AIPEGSHIKD NEQALYELVK CNFDTEEALR RLRF

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Dog, Zebrafish, African clawed frog, Chicken, Bovine, RabbitSpecies reactivity (tested):Human

Purification: Purified using Protein A affinity column

Immunogen: The immunogen for anti-MIER1 antibody: synthetic peptide directed towards the middle region of human MIER1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 100 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for MIER1

Target: MIER1 (Mesoderm Induction Early Response 1 (MIER1))

Alternative Name: MIER1 (MIER1 Products)

Synonyms: 4933425I22Rik antibody, 5830411K19Rik antibody, mKIAA1610 antibody, mier1 antibody, wu:fb30a02 antibody, zgc:56179 antibody, mi-er1 antibody, ER1 antibody, MI-ER1 antibody, RGD1562337 antibody, MEIR1 treanscription regulator antibody, MIER1 transcriptional regulator antibody, mesoderm induction early response 1a, transcriptional regulator antibody, mesoderm induction early response 1, transcriptional regulator L homeolog antibody, Mier1 antibody, MIER1 antibody, mier1a antibody, mier1.L antibody

Background: The association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters. Results demonstrate that alternate use of a facultative intron regulates the subcellular localization of hMI-ER1 proteins and this may have important implications for hMI-ER1 function in the regulation of transcription. Repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1).Synonyms: Early response 1, Er1, KIAA1610, Mesoderm induction early response protein 1, Mi-er1, hmi-er1

Gene ID: 57708

NCBI Accession: NP_065999

Pathways: Chromatin Binding