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MLH1 antibody (MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli))

Details for Product anti-MLH1 Antibody No. ABIN1108253, Supplier: Log in to see
Antigen
  • CG11482
  • Dmel\\CG11482
  • dmlh-1
  • dmlh1
  • zgc:66301
  • MLH1
  • LOC100232198
  • 1110035C23Rik
  • AI317206
  • AI325952
  • AI561766
  • COCA2
  • FCC2
  • HNPCC
  • HNPCC2
  • hMLH1
Alternatives
anti-Human MLH1 antibody for Immunohistochemistry (Frozen Sections)
Reactivity
Human, Monkey
140
40
39
6
5
2
1
1
1
1
1
1
Host
Mouse
93
49
Clonality (Clone)
Monoclonal ()
Conjugate
This MLH1 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
101
41
28
20
20
19
12
11
10
7
3
2
1
1
1
1
Supplier
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Clone 4C9C7
Isotype IgG1
Specificity Recognizes MLH1
Cross-Reactivity (Details) Species reactivity (tested):Human, Monkey.
Purification Ascites
Alternative Name MLH1 (MLH1 Antibody Abstract)
Background DNA-mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. Lack of a functional DNA-mismatch repair pathway is a commoncharacteristic of several different types of human cancers, either due to anMMR gene mutation or promoter-methylation gene silencing. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is an integralpart of the protein complex responsible for mismatch repair expressed inlymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid andgall bladder, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectalcancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. MLH1 also plays a role in meiotic recombination.Synonyms: COCA2, DNA mismatch repair protein Mlh1
Gene ID 4292
Research Area Cancer, DNA/RNA
Pathways DNA Damage Repair
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Immunofluorescence (IF) image for anti-MLH1 antibody (MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli)) (ABIN1108253) anti-MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) antibody
Immunohistochemistry (IHC) image for anti-MLH1 antibody (MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli)) (ABIN1108253) anti-MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) antibody (Image 2)
Western Blotting (WB) image for anti-MLH1 antibody (MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli)) (ABIN1108253) anti-MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) antibody (Image 3)
Background publications Geary, Sasieni, Houlston et al.: "Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC)." in: Familial cancer, Vol. 7, Issue 2, pp. 163-72, 2008 (PubMed).

Zeng, Kinsella: "A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells." in: Autophagy, Vol. 3, Issue 4, pp. 368-70, 2007 (PubMed).