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MNDA antibody (Myeloid Cell Nuclear Differentiation Antigen)

Details for Product anti-MNDA Antibody No. ABIN1108272, Supplier: Log in to see
Antigen
  • PYHIN3
  • A730048F03
  • Ifi205b
Reactivity
Human
58
Host
Rat
49
8
1
Clonality (Clone)
Monoclonal ()
Conjugate
This MNDA antibody is un-conjugated
3
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunofluorescence (IF)
46
32
22
18
10
3
1
1
1
1
Supplier
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Immunogen Concentrated nuclear protein extract prepared from late stage human myeloid leukemia HL-60 cells
Clone 3C1
Isotype IgG1
Specificity The antibody detects human myeloid nuclear differentiation antigen (MNDA). Cross reactivity to a similar protein in other species has not been extensively characterized.
Purification Affinity chromatography
Alternative Name MNDA (MNDA Antibody Abstract)
Background MNDA has been characterized as a cofactor in regulation of cell cycle progression, cell differentiation and apoptosis [2-4]. The human myeloid nuclear differentiation antigen, MNDA, is expressed only in myelomonocytic and a subset of B lymphoid hematopoietic cells [5]. MNDA is uniformly distributed throughout the interphase cell nucleus and associates with chromatin, but does not bind specific DNA sequences [6]. It is a member of the interferon-alpha inducible protein family and accordingly has been reported to be altered in a variety of inflammatory related disease states [3, 7-11]. Expression is disproportionately consistent in the marginal zone lymphoproliferative disorders subset of malignant lymphoma [12]. Expression is reported to be decreased in myelodysplasia in myeloid precursors and mature forms [13, 14].Synonyms: Myeloid cell nuclear differentiation antigen
Gene ID 4332
NCBI Accession NP_002423
UniProt P41218
Research Area Stem Cells, Hematopoietic Progenitors, Innate Immunity, Cytokines
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 0.1 % BSA and 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
Supplier Images
 image for anti-MNDA antibody (Myeloid Cell Nuclear Differentiation Antigen) (ABIN1108272) anti-Myeloid Cell Nuclear Differentiation Antigen (MNDA) antibody
Background publications Kanellis, Roncador, Arribas et al.: "Identification of MNDA as a new marker for nodal marginal zone lymphoma." in: Leukemia, Vol. 23, Issue 10, pp. 1847-57, 2009 (PubMed).

Choubey, Panchanathan: "Interferon-inducible Ifi200-family genes in systemic lupus erythematosus." in: Immunology letters, Vol. 119, Issue 1-2, pp. 32-41, 2008 (PubMed).

Choubey, Deka, Ho: "Interferon-inducible IFI16 protein in human cancers and autoimmune diseases." in: Frontiers in bioscience : a journal and virtual library, Vol. 13, pp. 598-608, 2007 (PubMed).

Mondini, Vidali, Airò et al.: "Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders." in: Annals of the New York Academy of Sciences, Vol. 1110, pp. 47-56, 2007 (PubMed).

Briggs, Shults, Flye et al.: "Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis." in: Cancer research, Vol. 66, Issue 9, pp. 4645-51, 2006 (PubMed).

Murphy: "Cytomics and location proteomics: automated interpretation of subcellular patterns in fluorescence microscope images." in: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 67, Issue 1, pp. 1-3, 2005 (PubMed).

Quesenberry, Abedi, Aliotta et al.: "Stem cell plasticity: an overview." in: Blood cells, molecules & diseases, Vol. 32, Issue 1, pp. 1-4, 2004 (PubMed).

Pradhan, Mijovic, Mills et al.: "Differentially expressed genes in adult familial myelodysplastic syndromes." in: Leukemia, Vol. 18, Issue 3, pp. 449-59, 2004 (PubMed).

Johnstone, Kerry, Trapani: "The human interferon-inducible protein, IFI 16, is a repressor of transcription." in: The Journal of biological chemistry, Vol. 273, Issue 27, pp. 17172-7, 1998 (PubMed).

Xie, Briggs, Morris et al.: "MNDA binds NPM/B23 and the NPM-MLF1 chimera generated by the t(3;5) associated with myelodysplastic syndrome and acute myeloid leukemia." in: Experimental hematology, Vol. 25, Issue 11, pp. 1111-7, 1997 (PubMed).

Briggs, Dworkin, Briggs et al.: "Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage." in: Journal of cellular biochemistry, Vol. 54, Issue 2, pp. 198-206, 1994 (PubMed).

Briggs, Burrus, Stickney et al.: "Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha." in: Journal of cellular biochemistry, Vol. 49, Issue 1, pp. 82-92, 1992 (PubMed).

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