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MNDA antibody (Myeloid Cell Nuclear Differentiation Antigen) (FITC)

Details for Product anti-MNDA Antibody No. ABIN1108273, Supplier: Log in to see
Antigen
  • A730048F03
  • Ifi205b
  • PYHIN3
Reactivity
Human
61
Host
Rat
51
9
1
Clonality (Clone)
Monoclonal ()
Conjugate
This MNDA antibody is conjugated to FITC
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunofluorescence (IF)
49
32
25
18
12
4
2
1
1
1
Supplier
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Immunogen Concentrated nuclear protein extract prepared from late stage human myeloid leukemia HL-60 cells
Clone 3C1
Isotype IgG1
Specificity The antibody detects human myeloid nuclear differentiation antigen (MNDA). Cross reactivity to a similar protein in other species has not been extensively characterized.
Purification Affinity chromatography
Alternative Name MNDA (MNDA Antibody Abstract)
Background MNDA has been characterized as a cofactor in regulation of cell cycle progression, cell differentiation and apoptosis [2-4]. The human myeloid nuclear differentiation antigen, MNDA, is expressed only in myelomonocytic and a subset of B lymphoid hematopoietic cells [5]. MNDA is uniformly distributed throughout the interphase cell nucleus and associates with chromatin, but does not bind specific DNA sequences [6]. It is a member of the interferon-alpha inducible protein family and accordingly has been reported to be altered in a variety of inflammatory related disease states [3, 7-11]. Expression is disproportionately consistent in the marginal zone lymphoproliferative disorders subset of malignant lymphoma [12]. Expression is reported to be decreased in myelodysplasia in myeloid precursors and mature forms [13, 14].Synonyms: Myeloid cell nuclear differentiation antigen
Gene ID 4332
NCBI Accession NP_002423
UniProt P41218
Research Area Stem Cells, Hematopoietic Progenitors, Innate Immunity, Cytokines
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 0.1 % BSA and 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
Supplier Images
 image for anti-MNDA antibody (Myeloid Cell Nuclear Differentiation Antigen)  (FITC) (ABIN1108273) anti-Myeloid Cell Nuclear Differentiation Antigen (MNDA) antibody (FITC)
Background publications Kanellis, Roncador, Arribas, Mollejo, Montes-Moreno, Maestre, Campos-Martin, Ríos Gonzalez, Martinez-Torrecuadrada, Sanchez-Verde, Pajares, Cigudosa, Martin, Piris: "Identification of MNDA as a new marker for nodal marginal zone lymphoma." in: Leukemia, Vol. 23, Issue 10, pp. 1847-57, 2009 (PubMed).

Choubey, Panchanathan: "Interferon-inducible Ifi200-family genes in systemic lupus erythematosus." in: Immunology letters, Vol. 119, Issue 1-2, pp. 32-41, 2008 (PubMed).

Mondini, Vidali, Airò, De Andrea, Riboldi, Meroni, Gariglio, Landolfo: "Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders." in: Annals of the New York Academy of Sciences, Vol. 1110, pp. 47-56, 2007 (PubMed).

Choubey, Deka, Ho: "Interferon-inducible IFI16 protein in human cancers and autoimmune diseases." in: Frontiers in bioscience : a journal and virtual library, Vol. 13, pp. 598-608, 2007 (PubMed).

Briggs, Shults, Flye, McClintock-Treep, Jagasia, Goodman, Boulos, Jacobberger, Stelzer, Head: "Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis." in: Cancer research, Vol. 66, Issue 9, pp. 4645-51, 2006 (PubMed).

Murphy: "Cytomics and location proteomics: automated interpretation of subcellular patterns in fluorescence microscope images." in: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 67, Issue 1, pp. 1-3, 2005 (PubMed).

Quesenberry, Abedi, Aliotta, Colvin, Demers, Dooner, Greer, Hebert, Menon, Pimentel, Paggioli: "Stem cell plasticity: an overview." in: Blood cells, molecules & diseases, Vol. 32, Issue 1, pp. 1-4, 2004 (PubMed).

Pradhan, Mijovic, Mills, Cumber, Westwood, Mufti, Rassool: "Differentially expressed genes in adult familial myelodysplastic syndromes." in: Leukemia, Vol. 18, Issue 3, pp. 449-59, 2004 (PubMed).

Xie, Briggs, Briggs: "Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding." in: Journal of cellular biochemistry, Vol. 70, Issue 4, pp. 489-506, 1998 (PubMed).

Johnstone, Kerry, Trapani: "The human interferon-inducible protein, IFI 16, is a repressor of transcription." in: The Journal of biological chemistry, Vol. 273, Issue 27, pp. 17172-7, 1998 (PubMed).

Xie, Briggs, Morris, Olson, Kinney, Briggs: "MNDA binds NPM/B23 and the NPM-MLF1 chimera generated by the t(3;5) associated with myelodysplastic syndrome and acute myeloid leukemia." in: Experimental hematology, Vol. 25, Issue 11, pp. 1111-7, 1997 (PubMed).

Briggs, Burrus, Stickney, Briggs: "Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha." in: Journal of cellular biochemistry, Vol. 49, Issue 1, pp. 82-92, 1992 (PubMed).