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MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) antibody

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Antigen
Synonyms
ATMSH2, MUTS homolog 2, AI788990, wu:fc06b02, wu:fc13e09, zgc:55333, COCA1, FCC1, HNPCC, HNPCC1, LCFS2, CG7895, DROHOXHK4, DROHOXNK4, DmNK-4, Dmel\CG7895, HOX, NK-4, NK-4/msh-2, NK4, NK4/msh-2, NKX2.5 ... show more
ATMSH2, MUTS homolog 2, AI788990, wu:fc06b02, wu:fc13e09, zgc:55333, COCA1, FCC1, HNPCC, HNPCC1, LCFS2, CG7895, DROHOXHK4, DROHOXNK4, DmNK-4, Dmel\CG7895, HOX, NK-4, NK-4/msh-2, NK4, NK4/msh-2, NKX2.5, TIN, Tin, msh-2, msh2, tin/NK4 show less
Alternatives
Reactivity
Human, Monkey
(174), (42), (27), (7), (5), (3), (3), (2), (1), (1), (1), (1), (1)
Host
Mouse
(121), (52), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(111), (50), (48), (46), (41), (26), (19), (19), (12), (11), (3), (1), (1)
Pubmed 2 references available
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Quantity 0.1 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Clone 1B3=3A2B8C
Isotype IgG1
Specificity Recognizes MSH2
Cross-Reactivity (Details) Species reactivity (tested):Human, Monkey.
Purification Ascites
Alternative Name MSH2 (MSH2 Antibody Abstract)
Background MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50 % of inherited non-polyposis colorectal (HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process.Synonyms: DNA mismatch repair protein Msh2, MutS protein homolog 2
Molecular Weight 105 kDa
Gene ID 4436
Research Area Cancer, DNA/RNA
Pathways DNA Damage Repair
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) antibody (ABIN1108301) anti-MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) antibody
Immunohistochemistry (IHC) image for anti-MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) antibody (ABIN1108301) anti-MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) antibody (Image 2)
Immunofluorescence (IF) image for anti-MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) antibody (ABIN1108301) anti-MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) antibody (Image 3)
Background publications Papadopoulos, Nicolaides, Wei et al.: "Mutation of a mutL homolog in hereditary colon cancer." in: Science (New York, N.Y.), Vol. 263, Issue 5153, pp. 1625-9, 1994 (PubMed).

Palombo, Hughes, Jiricny et al.: "Mismatch repair and cancer." in: Nature, Vol. 367, Issue 6462, pp. 417, 1994 (PubMed).

Catalog No. ABIN1108301
$335.50
Plus shipping costs $45.00

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