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Myelin Basic Protein (MBP) antibody

Details for Product No. ABIN1108334, Supplier: Login to see New
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Antigen
Synonyms cb274, fj33b11, mbp, wu:fj33b11, wu:fq15b02, zgc:136630, MGC115135, Mbps, C76307, Hmbpr, R75289, golli-mbp, mld, shi
Reactivity
Human
(156), (42), (30), (27), (16), (8), (7), (6), (6), (4), (3), (2), (2), (2), (1), (1), (1), (1)
Host
Mouse
(92), (87), (18), (11), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2)
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(134), (86), (56), (45), (41), (27), (21), (13), (10), (9), (7), (6), (4), (2), (1)
Pubmed 2 references available
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Quantity 0.1 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Clone 2H9
Isotype IgG1
Specificity This antibody reacts to MBP.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name Myelin Basic Protein (MBP Antibody Abstract)
Background The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.Synonyms: MBP, Myelin membrane encephalitogenic protein
Molecular Weight 33 kDa
Gene ID 4155
Research Area Glia marker, Cell/Tissue Markers
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Immunohistochemistry (IHC) image for anti-Myelin Basic Protein (MBP) antibody (ABIN1108334) anti-Myelin Basic Protein (MBP) antibody
Immunohistochemistry (IHC) image for anti-Myelin Basic Protein (MBP) antibody (ABIN1108334) anti-Myelin Basic Protein (MBP) antibody (Image 2)
Flow Cytometry (FACS) image for anti-Myelin Basic Protein (MBP) antibody (ABIN1108334) anti-Myelin Basic Protein (MBP) antibody (Image 3)
Immunofluorescence (IF) image for anti-Myelin Basic Protein (MBP) antibody (ABIN1108334) anti-Myelin Basic Protein (MBP) antibody (Image 4)
Western Blotting (WB) image for anti-Myelin Basic Protein (MBP) antibody (ABIN1108334) anti-Myelin Basic Protein (MBP) antibody (Image 5)
Western Blotting (WB) image for anti-Myelin Basic Protein (MBP) antibody (ABIN1108334) anti-Myelin Basic Protein (MBP) antibody (Image 6)
ELISA image for anti-Myelin Basic Protein (MBP) antibody (ABIN1108334) anti-Myelin Basic Protein (MBP) antibody (Image 7)
Background publications Rajaraman, Brenner, Butler et al.: "Common variation in genes related to innate immunity and risk of adult glioma." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 5, pp. 1651-8, 2009 (PubMed).

Hoos, Ahmed, Smith et al.: "Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro." in: Biochemistry, Vol. 48, Issue 22, pp. 4720-7, 2009 (PubMed).

Catalog No. ABIN1108334
$423.50
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