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NEFL antibody
NEFL
Reactivity: Human, Rat, Pig
WB, IHC (p), IHC (fro)
Host: Mouse
Monoclonal
NF-68
unconjugated
Product Details anti-NEFL Antibody
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Target
See all NEFL Antibodies
NEFL
(Neurofilament, Light Polypeptide (NEFL))
Reactivity
All reactivities for NEFL antibodies
Human, Rat, Pig
Host
All hosts for NEFL antibodies
Mouse
Clonality
All clonalities for NEFL antibodies
Monoclonal
Conjugate
All conjugates for NEFL antibodies
This NEFL antibody is un-conjugated
Application
All applications for NEFL antibodies
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
Specificity
This antibody reacts to Neurofilament L (68 kDa).
Purification
Affinity chromatography
Clone
NF-68
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Reconstitution
Restore with 1.2 % sodium acetate or neutral PBS
Concentration
0,1 mg/mL
Buffer
1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for NEFL
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Target
NEFL
(Neurofilament, Light Polypeptide (NEFL))
Alternative Name
Neurofilament L (68kDa) (NEFL Products )
Synonyms
NEFL antibody, nefl antibody, zgc:136626 antibody, AI847934 antibody, CMT2E antibody, NF-L antibody, NF68 antibody, Nfl antibody, CMT1F antibody, NFL antibody, XNF-L antibody, neurofilament light antibody, neurofilament, light polypeptide antibody, neurofilament, light polypeptide b antibody, neurofilament, light L homeolog antibody, NEFL antibody, neflb antibody, Nefl antibody, nefl.L antibody
Background
Neurofilaments are composed of 3 neuron-specific proteins with apparent molecular masses of 68 Kd (NFL), 125 kD (NFM) and 200 kD (NFH) on SDS-gel electrophoresis. And they have a role in the maturation of regenerating myelinated axons. Neurofilament 68 (NF68), also called Neurofilament rotein, Light Chain (NFL). It is one of the most abundant cytoskeletal omponents of the neuron.Mutations in this gene were reported as a cause for autosomal dominant Charcot-Marie-Tooth type 2E (CMT2E) linked to chromosome 8p21. NFL was identified repeatedly in both screenings and found to interact with Myotubularin-related 2 gene, MTMR2 in both Schwann cells and neurons.Synonyms: 68 kDa neurofilament protein, NEFL, NF-L, NF68, Neurofilament L
Gene ID
4747
NCBI Accession
NP_006149
UniProt
P07196
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