p53 antibody (Tumor Protein P53)

Details for Product anti-TP53 Antibody No. ABIN1108553, Supplier: Log in to see
Antigen
  • tp53
  • p53
  • TP53
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • TpMs
  • BCC7
  • LFS1
  • P53
  • TRP53
  • Trp53
  • Xp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • cellular tumor antigen p53
  • tumor protein p53
  • tumor supressor p53
  • p53 tumor suppressor
  • transformation related protein 53
  • transformation related protein 53, pseudogene
  • trichoplein, keratin filament binding
  • Wistar clone pR53P1 p53 pseudogene
  • CpipJ_CPIJ002758
  • TP53
  • tp53
  • P53
  • Trp53
  • Trp53-ps
  • TCHP
  • Tp53
  • p53-ps
Alternatives
anti-Human p53 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
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Host
Mouse
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1169
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3
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1
Clonality (Clone)
Monoclonal ()
Conjugate
This p53 antibody is un-conjugated
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78
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Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
1931
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Options
Supplier
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Supplier Product No.
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Immunogen Recombinant Human wild-type p53 protein.
Clone IMD-53
Isotype IgG2a
Specificity This antibody reacts to p53 (TP53).
Purification Affinity Chromatography
Alternative Name p53 (TP53) (TP53 Antibody Abstract)
Background The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.Synonyms: Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
Gene ID 7157
NCBI Accession NP_000537
UniProt P04637
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Reconstitution Restore with 1.2 % Sodium Acetate or neutral PBS
Concentration 0.1 mg/mL
Buffer 1.2 % Sodium Acetate with 2 mg BSA and 0.01 mg Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (IHC) image for anti-Tumor Protein P53 (TP53) antibody (ABIN1108553) anti-Tumor Protein P53 (TP53) antibody
Western Blotting (WB) image for anti-Tumor Protein P53 (TP53) antibody (ABIN1108553) anti-Tumor Protein P53 (TP53) antibody (Image 2)
Background publications Casey, Yamanaka, Friess, Kobrin, Lopez, Buchler, Beger, Korc: "p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis." in: Cancer letters, Vol. 69, Issue 3, pp. 151-60, 1993 (PubMed).

Isobe, Emanuel, Givol, Oren, Croce: "Localization of gene for human p53 tumour antigen to band 17p13." in: Nature, Vol. 320, Issue 6057, pp. 84-5, 1986 (PubMed).

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