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Peptidyl Arginine Deiminase, Type IV (PADI4) (C-Term) antibody

Details for Product No. ABIN1108565, Supplier: Login to see
Antigen
  • PAD
  • PAD4
  • PADI5
  • PDI4
  • PDI5
  • Pad4
  • Pdi4
Epitope
C-Term
16
13
4
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
94
8
6
1
1
1
1
1
1
1
Host
Rabbit
56
21
16
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
72
29
21
20
13
11
6
5
5
3
2
1
1
1
1
1
1
Supplier
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Immunogen A15 residue synthetic peptide derived from C-terminal domain of Human PADI4 protein
Specificity Reacts with 74 kDa PAD4 protein from Human, Mouse and Rat. No cross reaction with the other isoforms.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse, Rat.
Purification Serum
Alternative Name PADI4 (PADI4 Antibody Abstract)
Background PAD4 is a member of a family of enzymes responsible for the conversion of arginine residues to citrulline residues via catalyzation of the deimination of the arginine residues. PAD4 down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. This protein may play a role in granulocyte and macrophage development leading to inflammation and immune response.Synonyms: HL-60 PAD, PAD4, PADI-H, PADI5, PDI4, PDI5, Peptidylarginine deiminase IV, Protein-arginine deiminase type IV, Protein-arginine deiminase type-4
Gene ID 23569
NCBI Accession NP_036519
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Reconstitution Restore in distilled water.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store lyophilized antibody at -20 °C Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Wang, Wysocka, Sayegh et al.: "Human PAD4 regulates histone arginine methylation levels via demethylimination." in: Science (New York, N.Y.), Vol. 306, Issue 5694, pp. 279-83, 2004 (PubMed).