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PRKC, Apoptosis, WT1, Regulator (PAWR) antibody

Details for Product No. ABIN1108571, Supplier: Login to see
Antigen
  • MGC81382
  • pawrl
  • zgc:103513
  • PAWR
  • PAR4
  • Par-4
  • Par4
  • 2310001G03Rik
Reactivity
Human
64
21
21
4
2
2
Host
Mouse
60
3
1
Clonality (Clone)
Monoclonal ()
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
53
32
26
11
2
2
2
1
1
Supplier
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Clone 3G9H7
Isotype IgG1
Specificity Recognizes PRKC Apoptosis WT1 Regulator (PAWR).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name PAR4 / PAWR (PAWR Antibody Abstract)
Background Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor.Synonyms: PRKC apoptosis WT1 regulator protein, Par-4, Prostate apoptosis response 4 protein
Gene ID 5074
Research Area Apoptosis/Necrosis
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody (ABIN1108571) anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody
Immunohistochemistry (IHC) image for anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody (ABIN1108571) anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody (ABIN1108571) anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody (Image 3)
Immunohistochemistry (IHC) image for anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody (ABIN1108571) anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody (Image 4)
Background publications Weller, Dahl, Lohoff et al.: "No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence." in: Psychiatric genetics, Vol. 16, Issue 5, pp. 193-6, 2006 (PubMed).

Gurumurthy, Goswami, Vasudevan et al.: "Phosphorylation of Par-4 by protein kinase A is critical for apoptosis." in: Molecular and cellular biology, Vol. 25, Issue 3, pp. 1146-61, 2005 (PubMed).

Kukoc-Zivojnov, Puccetti, Chow et al.: "Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells." in: Experimental hematology, Vol. 32, Issue 7, pp. 649-56, 2004 (PubMed).

Xie, Guo: "Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane." in: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28266-75, 2004 (PubMed).