PRKC, Apoptosis, WT1, Regulator (PAWR) antibody

Details for Product No. ABIN1108571
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Antigen
Synonyms MGC81382, pawrl, zgc:103513, PAWR, PAR4, Par-4, Par4, 2310001G03Rik
Reactivity
Human
(60), (19), (18), (1)
Host
Mouse
(58), (2), (1)
Clonality (Clone)
Monoclonal ()
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(53), (26), (25), (15), (5), (4), (2), (2), (2), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1108571
434.50 $
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Clone 3G9H7
Isotype IgG1
Specificity Recognizes PRKC Apoptosis WT1 Regulator (PAWR).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name PAR4 / PAWR
Background Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor.Synonyms: PRKC apoptosis WT1 regulator protein, Par-4, Prostate apoptosis response 4 protein
Gene ID 5074
Research Area Apoptosis/Necrosis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody
anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody (2) anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody (Image 2)
anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody (3) anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody (Image 3)
anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody (4) anti-PRKC, Apoptosis, WT1, Regulator (PAWR) antibody (Image 4)
Background publications Xie, Guo: "Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane." in: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28266-75, 2004 (PubMed).

Kukoc-Zivojnov, Puccetti, Chow et al.: "Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells." in: Experimental hematology, Vol. 32, Issue 7, pp. 649-56, 2004 (PubMed).

Gurumurthy, Goswami, Vasudevan et al.: "Phosphorylation of Par-4 by protein kinase A is critical for apoptosis." in: Molecular and cellular biology, Vol. 25, Issue 3, pp. 1146-61, 2005 (PubMed).

Weller, Dahl, Lohoff et al.: "No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence." in: Psychiatric genetics, Vol. 16, Issue 5, pp. 193-6, 2006 (PubMed).

Validation Images
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