PGC antibody

Catalog No. ABIN1108614

Product Details anti-PGC Antibody

Target: PGC (Pepsinogen C (PGC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PGC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: The antibody clone L10CC10 is specific to Human Pepsinogen II and has no crossreactivity to Human Pepsinogen I.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ig Fraction

Immunogen: Pepsinogen II purified from Human tissue. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.

Clone: L10CC10

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.09 % Sodium Azide, 1.0 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for PGC

Target: PGC (Pepsinogen C (PGC))

Alternative Name: Pepsinogen Group II (PGC Products)

Synonyms: PEPC antibody, PGII antibody, 2210410L06Rik antibody, Upg-1 antibody, Upg1 antibody, CPGC antibody, gastricsin antibody, PG1 antibody, Pg-1 antibody, PGNC antibody, PGC antibody, Gastricsin antibody, progastricsin (pepsinogen C) antibody, progastricsin antibody, PGC antibody, Pgc antibody

Background: Pepsinogen II is a group of precursor molecules for pepsin. These proteins are secreted into the gastric lumen by the pyloric glands of the gastric antrum and also by the chief and neck cells of the gastric corpus (oxyntic mucosa). Negative immunohistochemical reaction for pepsinogen I (right) but positive reaction for pepsinogen II (left) is a typical sign of the antral mucosa and, in the presence of atrophic gastritis, this staining pattern indicates that the positive glands and cells are metaplastic and Synonyms: Gastricsin, PGC, Pepsinogen C, Progastricsin

Gene ID: 5225

NCBI Accession: NP_002621

UniProt: P20142