PHLDA2 antibody, ipl antibody, phlda2 antibody, BRW1C antibody, BWR1C antibody, HLDA2 antibody, IPL antibody, TSSC3 antibody, Ipl antibody, Tssc3 antibody, zgc:110459 antibody, pleckstrin homology like domain family A member 2 antibody, Pleckstrin homology-like domain family A member 2 antibody, pleckstrin homology like domain, family A, member 2 antibody, pleckstrin homology-like domain, family A, member 2 antibody, pleckstrin homology-like domain, family A, member 2 L homeolog antibody, PHLDA2 antibody, phla2 antibody, Phlda2 antibody, phlda2.L antibody, phlda2 antibody
Background
TSSC3 in encoded in the imprinted gene domain of 11p15.5 which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth.Synonyms: BWR1C, Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein, HLDA2, IPL, Imprinted in placenta and liver protein, Pleckstrin homology-like domain family A member 2, Tumor-suppressing STF cDNA 3 protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein, p17-Beckwith-Wiedemann region 1 C