PLVAP antibody (FITC)

Catalog No. ABIN1108673

Product Details anti-PLVAP Antibody (FITC)

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PLVAP antibody is conjugated to FITC

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein G

Clone: 174-2

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 1 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for PLVAP

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Alternative Name: PLVAP (PLVAP Products)

Synonyms: MECA32 antibody, Pv1 antibody, FELS antibody, PV-1 antibody, PV1 antibody, gp68 antibody, plasmalemma vesicle associated protein antibody, Plvap antibody, PLVAP antibody

Background: PLVAP is a 60 kDa type II transmembrane glycoprotein which tends to form homodimers. PLVAP is widely expressed in the vasculature of normal tissues. The vascular staining pattern of PLVAP is quite unique among the endothelial cell antigens, since expression of other antigens (like ICAM-1, P-selectin, E-selectin or VCAM-1) is not limited to vascular endothelial cells. PLVAP expression in the vascular endothelial cells of the CNS is lost in association with formation of an intact blood-brain barrier. However, in the endothelium of human brain tumors expression of PLVAP is specifically up-regulated, making it a suitable antiangiogenic target for brain tumor therapy and cerebral edema. Furthermore, PLVAP is expressed in the vasculature of most other human tumors and as such useful as marker for tumor angiogenesis.Synonyms: Endothelial Cell Antigen, Endothelial cell marker, Endothelial cell surface marker, FELS, Fenestrated endothelial-linked structure protein, MECA-32 antigen, PV-1, PV1, Plasmalemma vesicle protein 1, Plasmalemma vesicle-associated protein

UniProt: Q9BX97