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PRTN3 antibody

PRTN3 Reactivity: Human WB, IHC (fro), EIA, IHC (p), Func Host: Mouse Monoclonal WGM2 unconjugated
Catalog No. ABIN1108720
  • Target See all PRTN3 Antibodies
    PRTN3 (Proteinase 3 (PRTN3))
    Reactivity
    • 70
    • 11
    • 6
    • 1
    • 1
    • 1
    Human
    Host
    • 52
    • 26
    • 1
    • 1
    • 1
    Mouse
    Clonality
    • 57
    • 24
    Monoclonal
    Conjugate
    • 43
    • 10
    • 9
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PRTN3 antibody is un-conjugated
    Application
    • 59
    • 34
    • 21
    • 11
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)
    Specificity
    Monoclonal antibody WGM2 reacts with human proteinase 3 (PR3), a 30 kDa protein.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human
    Purification
    Protein G
    Clone
    WGM2
    Isotype
    IgG1
    Top Product
    Discover our top product PRTN3 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS, 0.1 % bovine serum albumin
    Storage
    4 °C
    Storage Comment
    Store at 2 - 8 °C.
  • Target
    PRTN3 (Proteinase 3 (PRTN3))
    Alternative Name
    PR3 / C-ANCA (PRTN3 Products)
    Synonyms
    ela2 antibody, MGC132250 antibody, ACPA antibody, AGP7 antibody, C-ANCA antibody, CANCA antibody, MBN antibody, MBT antibody, NP-4 antibody, NP4 antibody, P29 antibody, PR-3 antibody, PR3 antibody, mPR3 antibody, proteinase 3 L homeolog antibody, proteinase 3 antibody, prtn3.L antibody, PRTN3 antibody, Prtn3 antibody
    Background
    PR3 is a major antigen recognized by autoantibodies directed against cytoplasmic proteins of neutrophilic granulocytes and monocytes (so called anti-neutrophil cytoplasmic autoantibodies (ANCA)). ANCA are able to activate primed neutrophils to produce oxygen radicals and release lytic enzymes, including PR3. Proteinase 3 (PR3) was identified as the target antigen of ANCA in Wegener's granulomatosis (WG). ANCA directed against PR3 (PR3-ANCA) can interfere with the binding of PR3 to its physiological inhibitor alpha1-antitrypsin (alpha1-AT) and with the proteolytic activity of PR3. At the site of inflammation PR3 can cleave the complex between these inhibiting ANCA and PR3 itself, leaving active PR3. Autoantibodies to PR3 are potent activators of the 5-lipoxygenase pathway in primed human neutrophils. Extracellular free arachidonic acid, as present at an inflammatory focus, synergizes with such autoantibodies to evoke full-blown lipid mediator generation, granule secretion and respiratory burst. Proteinase 3 (PR3) is a neutral serine proteinase, which is localized in the azurophilic granules of neutrophils and in granules of monocytes and can be detected in the membrane of secretory vesicles. PR3 degrades a number of extracellular matrix proteins such as elastin and inactivates human C1 inhibitor. Membrane-associated PR3 is also able to activate caspase-3 without triggering apoptosis of neutrophils, which is possibly a neutrophil survival mechanism. In addition, PR3 is involved in myeloid differentiation and is, therefore, also called myeloblastin.Synonyms: AGP7, Leukocyte proteinase 3, MBN, Myeloblastin, NP-4, Neutrophil proteinase 4, P29, PR-3, PRTN3, Proteinase 3, Wegener autoantigen
    Gene ID
    5657
    NCBI Accession
    NP_002768
    UniProt
    P24158
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