Progesterone Receptor antibody (PGR)

Details for Product anti-PGR Antibody No. ABIN1108739, Supplier: Log in to see
Antigen
  • PR
  • XPR-1
  • pgr
  • xpr-2
  • PGR
  • pg
  • pr
  • gb:dq017620
  • NR3C3
  • 9930019P03Rik
  • BB114106
  • ENSMUSG00000074510
  • PR-A
  • PR-B
  • LOC443444
  • progesterone receptor
  • PGR
  • pgr-a
  • pgr
  • pr
  • Pgr
  • LOC443444
Alternatives
anti-Human Progesterone Receptor antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
561
97
93
22
15
14
13
10
7
6
5
5
3
2
1
1
1
1
1
1
Host
Mouse
336
237
3
Clonality (Clone)
Monoclonal ()
Conjugate
This Progesterone Receptor antibody is un-conjugated
17
17
14
9
9
9
2
2
2
2
2
2
2
2
2
2
2
Application
Western Blotting (WB)
421
158
144
137
100
59
48
27
22
9
8
7
3
2
2
1
1
1
Options
Supplier
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Supplier Product No.
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Clone 8A11H1
Isotype IgG1
Specificity Recognizes Progesterone Receptor (PGR)
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name Progesterone Receptor (PGR Antibody Abstract)
Background This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform A only, and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform B has not been clearly determined.Synonyms: NR3C3, Nuclear Receptor Subfamily 3 Group C Member 3, PGR, PR
Gene ID 5241
Research Area Cancer, Endocrine system, Transcription Factors, Hormones, Receptors
Pathways Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-Progesterone Receptor (PGR) antibody (ABIN1108739) anti-Progesterone Receptor (PGR) antibody
Background publications Yin, Lin, Cheng, Marsh, Utsunomiya, Ishikawa, Xue, Reierstad, Innes, Thung, Kim, Xu, Bulun: "Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells." in: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 11, pp. 4459-66, 2007 (PubMed).

Tung, Abdel-Hafiz, Shen, Harvell, Nitao, Richer, Sartorius, Takimoto, Horwitz: "Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B." in: Molecular endocrinology (Baltimore, Md.), Vol. 20, Issue 11, pp. 2656-70, 2006 (PubMed).

Buser, Gass-Handel, Wyszomierski, Doppler, Leonhardt, Schaack, Rosen, Watkin, Anderson, Edwards: "Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 21, Issue 1, pp. 106-25, 2006 (PubMed).

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