You are viewing an incomplete version of our website. Please click to reload the website as full version.

PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody

Details for Product No. ABIN1108769, Supplier: Log in to see
Antigen
  • PSIP1
  • im:7149861
  • zgc:109898
  • LEDGF
  • p75
  • PSIP2
  • DFS70
  • PAIP
  • p52
  • AA408851
  • AU015605
  • Dfs70
  • Ledgfa
  • Ledgfb
  • Psip2
  • Ledgf
  • SBP75
  • LEDGF/p75
Reactivity
Human, Monkey, Rat (Rattus)
36
18
14
7
3
3
1
Host
Mouse
29
16
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
40
21
7
7
7
6
4
2
2
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Available images

Clone 6-00E-004
Isotype IgG1
Specificity Recognizes PSIP1
Cross-Reactivity (Details) Species reactivity (tested):Human, Monkey, Rat.
Purification Ascites
Alternative Name PSIP1 (PSIP1 Antibody Abstract)
Background Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.Synonyms: CLL-associated antigen KW-7, DFS 70, DFS70, Dense fine speckles 70 kDa protein, LEDGF, Lens epithelium-derived growth factor, PC4 and SFRS1-interacting protein, PSIP1, PSIP2, Transcriptional coactivator p75/p52
Molecular Weight 75 kDa
Gene ID 11168
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
ELISA image for anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (ABIN1108769) anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody
Western Blotting (WB) image for anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (ABIN1108769) anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (Image 2)
Immunofluorescence (IF) image for anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (ABIN1108769) anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (Image 3)
Immunohistochemistry (IHC) image for anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (ABIN1108769) anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (Image 4)
Immunohistochemistry (IHC) image for anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (ABIN1108769) anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (Image 5)
Background publications Shun, Botbol, Li et al.: "Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity." in: Journal of virology, Vol. 82, Issue 23, pp. 11555-67, 2008 (PubMed).

Zhao, Li, Zeng et al.: "Insights into the interactions between HIV-1 integrase and human LEDGF/p75 by molecular dynamics simulation and free energy calculation." in: Proteins, Vol. 72, Issue 2, pp. 635-45, 2008 (PubMed).