PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody

Details for Product No. ABIN1108769
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Antigen
Synonyms PSIP1, im:7149861, zgc:109898, LEDGF, p75, PSIP2, DFS70, PAIP, p52, AA408851, AU015605, Dfs70, Ledgfa, Ledgfb, Psip2, Ledgf, SBP75, LEDGF/p75
Reactivity
Human, Monkey, Rat (Rattus)
(33), (13), (8), (7), (4), (3), (1)
Host
Mouse
(22), (14), (1)
Clonality (Clone)
Monoclonal ()
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(36), (21), (10), (9), (7), (6), (6), (4), (1)
Pubmed 2 references available
Quantity 0.1 mL
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Clone 6-00E-004
Isotype IgG1
Specificity Recognizes PSIP1
Cross-Reactivity (Details) Species reactivity (tested):Human, Monkey, Rat.
Purification Ascites
Alternative Name PSIP1 (PSIP1 Antibody Abstract)
Background Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.Synonyms: CLL-associated antigen KW-7, DFS 70, DFS70, Dense fine speckles 70 kDa protein, LEDGF, Lens epithelium-derived growth factor, PC4 and SFRS1-interacting protein, PSIP1, PSIP2, Transcriptional coactivator p75/p52
Molecular Weight 75 kDa
Gene ID 11168
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody
anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (2) anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (Image 2)
anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (3) anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (Image 3)
anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (4) anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (Image 4)
anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (5) anti-PC4 and SFRS1 Interacting Protein 1 (PSIP1) antibody (Image 5)
Background publications Shun, Botbol, Li et al.: "Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity." in: Journal of virology, Vol. 82, Issue 23, pp. 11555-67, 2008 (PubMed).

Zhao, Li, Zeng et al.: "Insights into the interactions between HIV-1 integrase and human LEDGF/p75 by molecular dynamics simulation and free energy calculation." in: Proteins, Vol. 72, Issue 2, pp. 635-45, 2008 (PubMed).

Validation Images
Catalog No. ABIN1108769
434.50 $
Plus shipping costs $45.00
Quantity
Price
0.1 mL
434.50 $

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