PTK7 antibody (N-Term)

Catalog No. ABIN1108790

Product Details anti-PTK7 Antibody

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTK7 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: This antibody reacts specifically with Human 112 kDa CCK-4.

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Chicken.
Species reactivity (tested):Human.

Purification: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide derived from Human N-terminal region of CCK-4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in distilled water.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer

Target Details for PTK7

Target: PTK7 (PTK7 Protein tyrosine Kinase 7 (PTK7))

Alternative Name: PTK7 / CCK4 (PTK7 Products)

Synonyms: PTK7 antibody, CCK-4 antibody, CCK4 antibody, Srf antibody, 8430404F20Rik antibody, chz antibody, mPTK7/CCK4 antibody, KLG antibody, protein tyrosine kinase 7 (inactive) antibody, protein tyrosine kinase 7 antibody, PTK7 protein tyrosine kinase 7 antibody, PTK7 antibody, Ptk7 antibody

Background: PTK7 is a member of the receptor tyrosine kinase family otherwise known as Colon Carcinoma Kinase 4 (CCK4). PTK7 is highly expressed in the kidney, liver, lung, pancreas and melanocytes with weaker expression being detected in the thyroid gland, ovaries, brain, heart and skeletal muscle. PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates. Studies also suggest that PTK7 may be involved in the tumour progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukaemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumour progression.Synonyms: CCK-4, Colon carcinoma kinase 4, Tyrosine-protein kinase-like 7

Gene ID: 5754

NCBI Accession: NP_002812

Pathways: RTK Signaling, Tube Formation