Retinoblastoma 1 (RB1) antibody

Details for Product No. ABIN1108867
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Antigen
Synonyms RB1, OSRC, RB, p105-Rb, pRb, pp110, Rb, Rb-1, zgc:154147, P105-RB, PP110, RB11
Reactivity
Human
(371), (229), (217), (109), (85), (65), (48), (7), (1), (1), (1)
Host
Mouse
(332), (52), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (10), (10), (10), (10), (10), (10), (10), (10), (10), (10)
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(242), (112), (100), (93), (79), (49), (37), (31), (18), (11), (8), (7), (3), (1)
Pubmed 2 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1108867
253.00 $
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  • +1 404 474 4654
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Clone 7E4B8
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name Retinoblastoma-Associated Protein / RB1
Background The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110
Gene ID 5925
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 0.03 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
anti-Retinoblastoma 1 (RB1) antibody anti-Retinoblastoma 1 (RB1) antibody
Background publications Weinberg: "The retinoblastoma protein and cell cycle control." in: Cell, Vol. 81, Issue 3, pp. 323-30, 1995 (PubMed).

Barrientes, Cooke, Goodrich: "Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function." in: Oncogene, Vol. 19, Issue 4, pp. 562-70, 2000 (PubMed).

Validation Images
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