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Retinoblastoma 1 antibody (RB1)

Details for Product anti-RB1 Antibody No. ABIN1108867, Supplier: Login to see
Antigen
  • RB1
  • OSRC
  • RB
  • p105-Rb
  • pRb
  • pp110
  • Rb
  • Rb-1
  • zgc:154147
  • P105-RB
  • PP110
  • RB11
Alternatives
anti-Human Retinoblastoma 1 antibody for Immunohistochemistry (Frozen Sections)
Reactivity
Human
526
254
230
11
8
7
5
5
4
4
3
3
2
2
Host
Mouse
468
67
3
Clonality (Clone)
Monoclonal ()
Conjugate
This Retinoblastoma 1 antibody is un-conjugated
22
20
20
15
13
13
10
9
9
7
7
7
7
7
7
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
323
216
184
83
73
73
45
35
15
13
10
7
6
5
2
2
2
1
1
Supplier
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Clone 7E4B8
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name Retinoblastoma-Associated Protein / RB1 (RB1 Antibody Abstract)
Background The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110
Gene ID 5925
Pathways Cell Division Cycle
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 0.03 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Immunohistochemistry (IHC) image for anti-Retinoblastoma 1 antibody (RB1) (ABIN1108867) anti-Retinoblastoma 1 (RB1) antibody
Background publications Barrientes, Cooke, Goodrich: "Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function." in: Oncogene, Vol. 19, Issue 4, pp. 562-70, 2000 (PubMed).

Weinberg: "The retinoblastoma protein and cell cycle control." in: Cell, Vol. 81, Issue 3, pp. 323-30, 1995 (PubMed).