EXOSC2 antibody

Catalog No. ABIN1108908

Product Details anti-EXOSC2 Antibody

Target: EXOSC2 (Exosome Component 2 (EXOSC2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EXOSC2 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Specificity: Specificity has been tested in ELISA. Additional tests for cross reactivity have not yet been performed.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Purified

Immunogen: Recombinant GST-hRRP4 (NCBI accession number NM_014285 REGION 3-884, expression vector pGEX-4T3), expressed in E.coli.

Clone: 15B3

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL (when dissolved at 0.5 mg/mL, the BSA concentration will be 1%)

Buffer: 10 mM Ammonium Bicarbonate buffer, 2 mg BSA

Precaution of Use: Be careful opening the vial since the antibody resides in a vacuum.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for EXOSC2

Target: EXOSC2 (Exosome Component 2 (EXOSC2))

Alternative Name: RRP4 / EXOSC2 (EXOSC2 Products)

Synonyms: EXOSC2 antibody, exosc2 antibody, MGC97533 antibody, RRP4 antibody, Rrp4p antibody, hRrp4p antibody, p7 antibody, Rrp4 antibody, fa97b01 antibody, wu:fa97b01 antibody, zgc:110117 antibody, exosome component 2 antibody, exosome component 2 L homeolog antibody, EXOSC2 antibody, exosc2 antibody, Bm1_33895 antibody, PTRG_00114 antibody, Exosc2 antibody, exosc2.L antibody

Background: The exosome, present in both the nucleus and cytoplasm of all eukaryotic cells, is a complex of 3'-5' exoribonucleases containing at least nine core components. Recently, it has been demonstrated, mainly by analyses in yeast, that the nuclear exosome is essential for rRNA processing and sn(o)RNA biogenesis. Furthermore, it is involved in the degradation of improperly processed mRNAs. The cytoplasmic exosome participates in normal mRNA turnover and in the degradation of inherently instable mRNAs that contain AU-rich elements. Therefore, the exosome plays a key role in RNA metabolism.Synonyms: Exosome complex exonuclease RRP4, Exosome component 2, Ribosomal RNA-processing protein 4

Gene ID: 23404

NCBI Accession: NP_055100

UniProt: Q13868

Pathways: SARS-CoV-2 Protein Interactome