SCARB1 antibody

Catalog No. ABIN1108937

Product Details anti-SCARB1 Antibody

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This SCARB1 antibody is un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Specificity: This antibody reacts with rat class B scavenger receptor type I (SR-BI). It blocks the biological activity of rat SR-BI. For example, it inhibits the ability of SR-BI to mediate the corporation of lipids of HDL by SR-BI expressing cells.

Cross-Reactivity (Details): Species reactivity (tested):Rat

Purification: Protein G

Clone: SR-BI

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for SCARB1

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Alternative Name: SCARB1 (SCARB1 Products)

Synonyms: cb1015 antibody, SCARB1 antibody, Scarb1 antibody, CD36L1 antibody, CLA-1 antibody, CLA1 antibody, HDLQTL6 antibody, SR-BI antibody, SRB1 antibody, AI120173 antibody, CD36 antibody, Cd36l1 antibody, Cla-1 antibody, Cla1 antibody, D5Ertd460e antibody, Hdlq1 antibody, Hlb398 antibody, SR-B1 antibody, SRBI antibody, Srb1 antibody, mSR-BI antibody, scavenger receptor class B, member 1 antibody, scavenger receptor class B member 1 antibody, scarb1 antibody, SCARB1 antibody, Scarb1 antibody, CpipJ_CPIJ014332 antibody, CpipJ_CPIJ019101 antibody

Background: Scavenger receptors have been studied primarily for their ability to bind and internalize modified lipoproteins. They have been found in the development of atherosclerosis and other macrophage-associated functions. Scavenger receptors also function as pattern recognition receptors for a wide variety of pathogens. This finding indicates a potential role in host defense. SR-BI belongs together with CD36 to the class B scavenger receptor family. SR-BI is a multiligand membrane protein existing in various organs such as the liver and various cell types such as endothelial cells, macrophages, brain cells, Leydig cells and Sertoli cells. SR-BI has been found as a receptor for phospholipids, free and (lipo)protein-bound ApoE, lipid-bound ApoA-I, HDL, hypochlorite-modified LDL and more. In liver, the PDZK-1 (and possible other PDZ domains) of SR-BI has been found to be essential for cell surface expression and, hence, reverse cholesterol transport. In the brain, the presence of SR-BI seems to be involved in the uptake of oxidatively modified lipoproteins and beta-amyloid protein complexed with ApoE, suggesting SR-BI to be an important tool for studies on neurodegenerative disorders. In the testis, SR-BI is expressed in two somatic cell types: Leydig cells and Sertoli cells. SR-BI functions at least partly as a phosphatidyl serine receptor (PSR), enabling Sertoli cells to recognize and phagocytose apoptotic spermatogenic cells at all stages of differentiation.Synonyms: CD36 and LIMPII analogous 1, CD36 antigen-like 1, CD36L1, CLA-1, CLA1, Collagen type I receptor thrombospondin receptor-like 1, SR-BI, SRB1, Scavenger receptor class B member 1

Gene ID: 25073

NCBI Accession: NP_113729

UniProt: P97943

Pathways: Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Lipid Metabolism, SARS-CoV-2 Protein Interactome