SIRT1 antibody (Sirtuin 1)

Details for Product anti-SIRT1 Antibody No. ABIN1109014, Supplier: Log in to see
Antigen
  • sirtuin 1
  • AA673258
  • SIR2L1
  • Sir2
  • Sir2a
  • Sir2alpha
  • sir2l1
  • sirtuin
  • SIR2
  • sirtuin 1
  • SIRT1
  • SRT1
  • LOC100349271
  • Sirt1
  • sirt1
Alternatives
anti-Human SIRT1 antibody for Immunocytochemistry
Reactivity
Human, Monkey
306
138
70
21
13
11
7
7
7
6
5
4
4
2
2
2
2
1
Host
Mouse
206
86
27
6
3
Clonality (Clone)
Monoclonal ()
Conjugate
This SIRT1 antibody is un-conjugated
17
14
10
7
7
6
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
255
132
88
66
60
51
41
40
36
7
5
5
4
2
2
2
2
2
1
1
Options
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Supplier Product No.
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Clone 1F3
Isotype IgG1
Specificity Recognizes SIRT1
Cross-Reactivity (Details) Species reactivity (tested):Human, Monkey.
Purification Ascites
Alternative Name SIRT1 (SIRT1 Antibody Abstract)
Background The Sir2 protein in yeast is known to function in transcriptional silencing processes through the deacetylation of histones H3 and H4. The more recently described human homologue of Sir2, known as SIRT1, has been found to associate with the tumor suppressor protein p53.SIRT1 binds and deacetylates p53 with specificity for its C-terminal Lys382 residue in response to the upregulation of promyelocytic leukemia protein (PML) nuclear bodies or oncogenic Ras. The deacetylation of p53 SIRT1 has been shown to negatively regulate p53-mediated transcription, preventing cellular senescence and apoptosis induced by DNA damage and stress.SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues, with high expression in heart, brain and skeletal muscle and low expression in lung and placenta. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lysine 382.Synonyms: NAD-dependent deacetylase sirtuin-1, S. cerevisiae, SIR2-like protein 1, SIR2L1, SIR2alpha, SIRT-1, homolog) 1, sirtuin (silent mating type information regulation 2, sirtuin 1, sirtuin type 1, sirtuin-1
Molecular Weight 120 kDa
Gene ID 23411
Research Area Chromatin and Nuclear Signaling, Apoptosis/Necrosis, Proteases
Pathways MAPK Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Negative Regulation of intrinsic apoptotic Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Flow Cytometry (FACS) image for anti-Sirtuin 1 (SIRT1) antibody (ABIN1109014) anti-Sirtuin 1 (SIRT1) antibody
Western Blotting (WB) image for anti-Sirtuin 1 (SIRT1) antibody (ABIN1109014) anti-Sirtuin 1 (SIRT1) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-Sirtuin 1 (SIRT1) antibody (ABIN1109014) anti-Sirtuin 1 (SIRT1) antibody (Image 3)
Immunofluorescence (IF) image for anti-Sirtuin 1 (SIRT1) antibody (ABIN1109014) anti-Sirtuin 1 (SIRT1) antibody (Image 4)
Background publications Sowa, Bennett, Gygi, Harper: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Xie, Park, Kim, Hwang, Oh, Park, Shong, Lee, Choi: "Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28762-74, 2009 (PubMed).

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