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SMAD6 antibody (SMAD, Mothers Against DPP Homolog 6)

Details for Product anti-SMAD6 Antibody No. ABIN1109064, Supplier: Log in to see
Antigen
  • AOVD2
  • b2b390Clo
  • hst17432
  • HsT17432
  • Madh6
  • madh6
  • MADH6
  • MADH7
  • madh7
  • smad6
  • Smad6-like
  • wu:fb22g05
  • Xsmad6
Reactivity
Human
116
34
11
2
2
1
1
1
1
Host
Mouse
93
47
Clonality (Clone)
Monoclonal ()
Conjugate
This SMAD6 antibody is un-conjugated
4
4
4
4
4
4
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
127
81
28
26
23
5
4
3
2
2
Supplier
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Supplier Product No.
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Clone 5H3
Isotype IgG1
Specificity Recognizes SMAD6
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name SMAD6 (SMAD6 Antibody Abstract)
Background Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.Synonyms: MAD homolog 6, MADH6, Mothers against DPP homolog 6, Mothers against decapentaplegic homolog 6, SMAD 6, SMAD family member 6, SMAD-6
Molecular Weight 53 kDa
Gene ID 4091
Research Area Cardiovascular, Hypertrophy, Cardiogenesis, Signaling, Transcription Factors
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-SMAD6 antibody (SMAD, Mothers Against DPP Homolog 6) (ABIN1109064) anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody
Background publications Shintani, Yagi, Nakayama, Saji, Matsuoka: "A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension." in: Journal of medical genetics, Vol. 46, Issue 5, pp. 331-7, 2009

Shen, Chen, Wang, Kaneki, Xing, Okeefe, Chen: "Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3569-76, 2006

Choi, Lee, Lim, Choi, Lee, Lee, Hong, Kim, Kim, Park: "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1." in: Nature immunology, Vol. 7, Issue 10, pp. 1057-65, 2006