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SMN1 / SMN2 antibody

Details for Product No. ABIN1109075, Supplier: Log in to see
Antigen
Reactivity
Human, Mouse (Murine)
15
2
Host
Mouse
12
3
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
15
10
3
2
1
1
1
Supplier
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Clone 1-00E-007
Isotype IgG1
Specificity This antibody reacts to c-Rel.
Cross-Reactivity (Details) Species reactivity (tested):Human and Mouse.
Purification Ascites
Background The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor.Synonyms: Component of gems 1, Gemin-1, Gemin1, SMN, SMNC, SMNT, Survival motor neuron protein
Molecular Weight 78 kDa
Gene ID 6606
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Immunohistochemistry (IHC) image for anti-SMN1 / SMN2 antibody (ABIN1109075) anti-SMN1 / SMN2 antibody
Immunofluorescence (IF) image for anti-SMN1 / SMN2 antibody (ABIN1109075) anti-SMN1 / SMN2 antibody (Image 2)
Western Blotting (WB) image for anti-SMN1 / SMN2 antibody (ABIN1109075) anti-SMN1 / SMN2 antibody (Image 3)
ELISA image for anti-SMN1 / SMN2 antibody (ABIN1109075) anti-SMN1 / SMN2 antibody (Image 4)
Background publications Trynka, Zhernakova, Romanos et al.: "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. ..." in: Gut, Vol. 58, Issue 8, pp. 1078-83, 2009 (PubMed).

Garbati, Gilmore: "Ser484 and Ser494 in REL are the major sites of IKK phosphorylation in vitro: evidence that IKK does not directly enhance GAL4-REL transactivation." in: Gene expression, Vol. 14, Issue 4, pp. 195-205, 2008 (PubMed).