SOCS4 antibody (C-Term)

Catalog No. ABIN1109094

Product Details anti-SOCS4 Antibody

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Binding Specificity: C-Term

Reactivity: Human, Cow, Pig

Host: Goat

Clonality: Polyclonal

Conjugate: This SOCS4 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequence: C-SKVRVLRIDA PEQQ

Specificity: This antibody detects SOCS-4 at C-term.

Cross-Reactivity (Details): Species reactivity (expected):Pig, Bovine.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide with sequence from the C Terminus of Human SOCS4 (NP_543143.1, NP_955453.1). Genename: SOCS4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SOCS4

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Alternative Name: SOCS4 (SOCS4 Products)

Synonyms: SOCS7 antibody, socs4 antibody, SOCS4 antibody, 3110032M18Rik antibody, A730004F22Rik antibody, AI427843 antibody, AU015727 antibody, AU015859 antibody, Socs7 antibody, SOCS6 antibody, socs7 antibody, socs4a antibody, suppressor of cytokine signaling 4 antibody, SOCS4 antibody, socs4 antibody, Socs4 antibody

Background: Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling) (1-3). Currently, there are eight members of the SOCS family that have been recognized, SOCS-1, -2, -3, -4, - 5, -6, -7 and CIS. Structurally, the SOCS proteins are composed of an N-terminus region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminus motif that has been called the SOCS box (4). The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STATinduced transcriptional mechanism (5). Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. Within the SOCS subfamily, SOCS-4, SOCS-5, SOCS-6, SOCS-7 remain poorly understood (6). On the basis of structural considerations, it would be expected that SOCS-4, -5, -6, and -7, like SOCS-1, SOCS-2, SOCS-3 and CIS, act to negatively regulate signal transduction (4), but it is uncertain which specific cytokine is involved (7-9).Synonyms: SOCS-4, SOCS-7, SOCS7, Suppressor of cytokine signaling 4, Suppressor of cytokine signaling 7

Gene ID: 122809

NCBI Accession: NP_543143

UniProt: Q8WXH5

Pathways: JAK-STAT Signaling, EGFR Signaling Pathway