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SPTA1 antibody
SPTA1
Reactivity: Human
WB
Host: Mouse
Monoclonal
Spe 1-2
unconjugated
Product Details anti-SPTA1 Antibody
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Target
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SPTA1
(Spectrin alpha 1, Erythrocytic (SPTA1))
Reactivity
All reactivities for SPTA1 antibodies
Human
Host
All hosts for SPTA1 antibodies
Mouse
Clonality
All clonalities for SPTA1 antibodies
Monoclonal
Conjugate
All conjugates for SPTA1 antibodies
This SPTA1 antibody is un-conjugated
Application
All applications for SPTA1 antibodies
Western Blotting (WB)
Specificity
This antibody reacts to Spectrin (erythrocyte) (alpha / beta).
Purification
Affinity chromatography
Immunogen
Human erythrocyte spectrin
Clone
Spe 1-2
Isotype
IgG1
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Reconstitution
Restore with 1.2 % sodium acetate or neutral PBS
Concentration
0,1 mg/mL
Buffer
1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for SPTA1
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Target
SPTA1
(Spectrin alpha 1, Erythrocytic (SPTA1))
Alternative Name
Spectrin alpha Chain (Erythrocyte) / SPTA1 (SPTA1 Products )
Synonyms
Spna1 antibody, AF093576 antibody, AI451697 antibody, Spna-1 antibody, ha antibody, ihj antibody, nmf4 antibody, sph antibody, EL2 antibody, HPP antibody, HS3 antibody, SPH3 antibody, SPTA antibody, spectrin, alpha, erythrocytic 1 antibody, spectrin alpha, erythrocytic 1 antibody, Spta1 antibody, SPTA1 antibody
Background
Spectrin, the predominant component of the membrane skeleton of the red cell, is essential in determining the properties of the membrane including its shape and deformability. It consists of 2 nonidentical subunits, alpha and beta. Spectrin is present in the red cell membrane in a tetrameric or possibly higher polymeric form through head-to-head self-association of heterodimers that are linked by actin polymers and protein 4.1 to form a 2-dimensional network. Non-erythroid spectrin gene is mapped to human chromosome 2.Spectrin mutations cause spinocerebellar ataxia type 5.Synonyms: Erythroid alpha-spectrin, SPTA
Gene ID
6708
NCBI Accession
NP_003117
UniProt
P02549
Pathways
Regulation of Actin Filament Polymerization
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