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SPTAN1 antibody

SPTAN1 Reactivity: Human WB, IHC (fro), EIA Host: Mouse Monoclonal AA6 unconjugated
Catalog No. ABIN1109119
  • Target See all SPTAN1 Antibodies
    SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))
    Reactivity
    • 76
    • 39
    • 39
    • 21
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 101
    • 15
    • 1
    Mouse
    Clonality
    • 92
    • 25
    Monoclonal
    Conjugate
    • 59
    • 21
    • 13
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SPTAN1 antibody is un-conjugated
    Application
    • 81
    • 46
    • 21
    • 20
    • 15
    • 14
    • 14
    • 11
    • 9
    • 7
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
    Specificity
    The antibody clone AA6 is specific to the 240 kDa Alpha-Fodrin molecule of all Mammalian nonerythroid cells and Chicken Alpha-Spectrin.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Rat, Chicken, Rabbit and Guinea Pig.
    Purification
    Ig Fraction
    Immunogen
    Chicken red blood cell membranes purified by hypotonic lysis and mechanical enucleation. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
    Clone
    AA6
    Isotype
    IgG1
    Top Product
    Discover our top product SPTAN1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    PBS, 0.09 % Sodium Azide, 1.0 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))
    Alternative Name
    Spectrin alpha Chain (Brain) / SPTAN1 (SPTAN1 Products)
    Synonyms
    im:7157190 antibody, wu:fa20e05 antibody, wu:fb33g08 antibody, wu:fk32a10 antibody, zgc:112229 antibody, 2610027H02Rik antibody, Spna-2 antibody, Spna2 antibody, EIEE5 antibody, NEAS antibody, SPTA2 antibody, A2a antibody, IPF antibody, SPECA antibody, spectrin alpha, non-erythrocytic 1 antibody, spectrin, alpha, non-erythrocytic 1 antibody, SPTAN1 antibody, sptan1 antibody, Sptan1 antibody
    Background
    Fodrin is a universally expressed membrane associated cytoskeletal protein consisting of alpha and beta subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. Alpha Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases generating N terminal 150 kDa, C terminal 120 kDa, and 35 kDa major products. Cleavage of alpha Fodrin leads to membrane malfunction and cell shrinkage.Synonyms: Alpha-II spectrin, Fodrin alpha chain, SPTA2, Spectrin non-erythroid alpha chain
    Gene ID
    374234
    NCBI Accession
    NP_001036003
    UniProt
    P07751
    Pathways
    Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization
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