SERPINB9 antibody

Catalog No. ABIN1109125

Product Details anti-SERPINB9 Antibody

Target: SERPINB9 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINB9 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificity: The antibody recognizes Mouse Spi-6, also known as Serpin B9, a cytoplasmic serine protease inhibitor of ~42 kDa. It shows no crossreactivity with Mouse proteins related to Spi-6.

Cross-Reactivity (Details): Species reactivity (tested):Mouse.

Purification: Protein A Chromatography

Immunogen: Recombinant GST-Spi-6

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % Sodium Azide, 0.1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8 °C.

Target Details for SERPINB9

Target: SERPINB9 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9))

Alternative Name: Spi-6 (SERPINB9 Products)

Synonyms: SERPINB9 antibody, BB283241 antibody, CAP-3 antibody, CAP3 antibody, PI-9 antibody, PI9 antibody, Spi6 antibody, ovalbumin antibody, serpin family B member 9 antibody, serpin peptidase inhibitor, clade B (ovalbumin), member 9 antibody, serine (or cysteine) peptidase inhibitor, clade B, member 9 antibody, Serpinb9 antibody, SERPINB9 antibody

Background: Spi-6 is expressed in dendritic cells, lymphocytes and specific cell types at immune-privileged sites. It inactivates granzyme B, a natural occurring inducer of programmed cell death. As such, Spi-6 functions as anti-apoptotic protein. In cytotxic T cells (CTL), Spi-6 is required to protect clonal bursts (expansion) from granzyme B induced cell death. However, it is not required for the development of memory cells. Expression of SPI-6 is of crucial importance in the escape of several tumors from a CTL response and is, therefore, a parameter that influences the feasibility of CTL-mediated immunotherapy of cancer.Synonyms: Cytoplasmic antiproteinase 3, PI-9, serpin B9

Gene ID: 20723

NCBI Accession: NP_033282

UniProt: O08797