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Details for Product No. ABIN1109197

TAG72 antibody

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Antigen
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
Pubmed 6 references available
Catalog no. ABIN1109197
Quantity 1 mL
Price
500.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Clone B72-3
Isotype IgG1
Specificity This antibody clone B72.3 recognizes a High Molecular Weight Glycoprotein called TAG-72 that is present in Human adenocarcinomas and in lesser amounts, non-neoplastic tissues. It has also been found to be useful to distinguish between mesothelioma and adenocarcinoma, however, false positive reactions can occur so results must be interpreted with the utmost caution.
Purification Ascites
Background The majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary, and non-small cell lung cancer display some cell populations that are positive for TAG72. About 60% of carcinoma patients express TAG72 in their sera. TAG72 is reportedly useful in distinguishing pulmonary adenocarcinomas from pleural mesotheliomas.
Alternate names: CA 72-4, CA72-4, TAG-72, sialy-Tn
Research Area Tags/Labels
Restrictions For Research Use only
Format Liquid
Buffer PBS, pH 7.4 0.09% Sodium Azide 0.9% BSA
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Osteen, Anderson, Schwartz et al.: "Distribution of tumor-associated glycoprotein-72 (TAG-72) expression throughout the normal female reproductive tract." in: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, Vol. 11, Issue 3, pp. 216-20, 1992 (PubMed).

Johnston, Szpak, Lottich et al.: "Use of a monoclonal antibody (B72.3) as a novel immunohistochemical adjunct for the diagnosis of carcinomas in fine needle aspiration biopsy specimens." in: Human pathology, Vol. 17, Issue 5, pp. 501-13, 1986 (PubMed).

Kline, Lundy, Lozowski: "Monoclonal antibody B72.3. An adjunct for evaluation of suspicious aspiration biopsy cytology from the breast." in: Cancer, Vol. 63, Issue 11, pp. 2253-6, 1989 (PubMed).

Lundy, Lozowski, Mishriki: "Monoclonal antibody B72.3 as a diagnostic adjunct in fine needle aspirates of breast masses." in: Annals of surgery, Vol. 203, Issue 4, pp. 399-402, 1986 (PubMed).

Ordóñez: "Role of immunohistochemistry in distinguishing epithelial peritoneal mesotheliomas from peritoneal and ovarian serous carcinomas." in: The American journal of surgical pathology, Vol. 22, Issue 10, pp. 1203-14, 1998 (PubMed).

Chhieng, Rodriguez-Burford, Talley et al.: "Expression of CEA, Tag-72, and Lewis-Y antigen in primary and metastatic lesions of ovarian carcinoma." in: Human pathology, Vol. 34, Issue 10, pp. 1016-21, 2003 (PubMed).

Alternatives for antigen "TAG72", type "Antibodies"
Hosts (13)
Reactivities (12), (1), (1), (1), (1)
Applications (10), (6), (3), (2), (2), (1), (1), (1)
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