Thyroglobulin (TG) antibody

Details for Product No. ABIN1109250
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Antigen
Synonyms TG, cb717, AITD3, TGN, Tgn, cog
Reactivity
Human
(217), (25), (20), (19), (15), (14), (3), (2), (1), (1)
Host
Mouse
(150), (64), (7), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (6), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
(112), (90), (45), (30), (25), (13), (13), (10), (9), (9), (6), (5), (4), (4), (4), (4), (2), (2), (1)
Pubmed 2 references available
Quantity 1 mL
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Catalog No. ABIN1109250
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Clone MRQ-41
Isotype IgG1
Specificity This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Anti-Thyroglobulin, combined with TTF1 are demonstrable by immunohistochemistry assay in the majority of thyroid neoplasms. A panel of antibodies for Thyroglobulin, TTF1, CK-7, CK19, and CK20 is useful when thyroid is the possible primary site of a metastatic tumor.
Purification Supernatant
Background Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells.
Alternate names: TGN, Thyreoglobulin
Gene ID 7038
NCBI Accession NP_003226
UniProt P01266
Research Area Hormones
Restrictions For Research Use only
Format Liquid
Buffer PBS, pH 7.4 0,09% sodium azide 0,9% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Bellet, Schlumberger, Bidart et al.: "Production and in vitro utilization of monoclonal antibodies to human thyroglobulin." in: The Journal of clinical endocrinology and metabolism, Vol. 56, Issue 3, pp. 530-3, 1983 (PubMed).

Bejarano, Nikiforov, Swenson et al.: "Thyroid transcription factor-1, thyroglobulin, cytokeratin 7, and cytokeratin 20 in thyroid neoplasms." in: Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry, Vol. 8, Issue 3, pp. 189-94, 2000 (PubMed).

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