TIMD4 antibody

Catalog No. ABIN1109254

Product Details anti-TIMD4 Antibody

Target: TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This TIMD4 antibody is un-conjugated

Application: Immunofluorescence (IF), Enzyme Immunoassay (EIA), Functional Studies (Func)

Specificity: The monoclonal antibody Kat5-18 recognizes T-cell immunoglobulin and mucin domain containing molecule (TIMD-4, also called TIM-4).

Cross-Reactivity (Details): Species reactivity (tested):Mouse

Purification: Purified

Immunogen: Mouse peritoneal cells

Clone: Kat5-18

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for TIMD4

Target: TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))

Alternative Name: TIMD4 (TIMD4 Products)

Synonyms: RGD1564516 antibody, MGC99322 antibody, TIMD4 antibody, B430010N18Rik antibody, TIM-4 antibody, Tim4 antibody, SMUCKLER antibody, TIM4 antibody, T-cell immunoglobulin and mucin domain containing 4 antibody, T-cell immunoglobulin and mucin domain containing 4 L homeolog antibody, T cell immunoglobulin and mucin domain containing 4 antibody, Timd4 antibody, TIMD4 antibody, timd4.L antibody

Background: TIMD-4 is a type I transmembrane protein belonging to the immunoglobulin superfamily, containing one Ig-like V-type (immunoglobulin-like) domain. TIMD-4 is expressed in Mac1+ cells in spleen, lymph nodes and fetal liver. TIMD-4 binds apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. TIMD-4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIMD-4 is involved in regulating T-cell proliferation and lymphotoxin signaling. TIMD-4 and TIMD-1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and are also involved in intracellular signaling in which exosomes are involved.Synonyms: T-cell immunoglobulin and mucin domain-containing protein 4, T-cell membrane protein 4, TIM-4, TIM4, TIMD-4

Gene ID: 276891

NCBI Accession: NP_848874

UniProt: Q6U7R4

Pathways: Cancer Immune Checkpoints