TIMP4 antibody (C-Term)

Catalog No. ABIN1109259

Product Details anti-TIMP4 Antibody

Target: TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMP4 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects TIMP4 (C-term). No cross reactivity with other proteins.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Immunogen affinity purified

Immunogen: A peptide mapping at the C-terminal end of human TIMP-4 .Remarks: Sequence is different from the related mouse sequence by three amino acids.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: 1.2 % sodium acetate or neutral PBS. If 0.5 mL of PBS is used, the antibody concentration will be 100 μg/mL.

Buffer: 50 % glycerol, 0.9 mg NaCl, 0.2 mg Na2HPO4

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for TIMP4

Target: TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

Alternative Name: TIMP4 (TIMP4 Products)

Synonyms: TIMP4 antibody, TIMP-4 antibody, timp4 antibody, TIMP metallopeptidase inhibitor 4 antibody, TIMP metallopeptidase inhibitor 4, tandem duplicate 3 antibody, tissue inhibitor of metalloproteinase 4 antibody, TIMP4 antibody, timp4.3 antibody, Timp4 antibody

Background: The tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. TIMP4 gene contains 5 exons that span 6 kb of genomic DNA.The gene is expressed as a 1.4-kb transcript abundant in heart and present at low levels in several other tissues. expressed TIMP4 inhibits MMPs in vitro. TIMP4 gene is mapped to chromosome 3p25. TIMP-4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2.Synonyms: Metalloproteinase inhibitor 4, TIMP-4, Tissue inhibitor of metalloproteinases 4

Gene ID: 7079

NCBI Accession: NP_003247

UniProt: Q99727