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Tyrosine Kinase, Non-Receptor, 1 (TNK1) antibody

Details for Product No. ABIN1109278, Supplier: Log in to see
Antigen
  • Kos1
  • Tnk1a
  • Tnk1b
  • Ack-like
Reactivity
Human
93
47
19
Host
Mouse
90
26
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
8
8
8
7
7
7
2
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
97
68
37
13
10
2
1
1
1
Supplier
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Clone 1B5G3
Isotype IgG1
Specificity Recognizes TNK1 (tyrosine kinase, non-receptor 1).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name TNK1 (TNK1 Antibody Abstract)
Background TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47- kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.Synonyms: CD38 negative kinase 1, Kos1, Non-receptor tyrosine-protein kinase TNK1
Gene ID 8711
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-Tyrosine Kinase, Non-Receptor, 1 (TNK1) antibody (ABIN1109278) anti-Tyrosine Kinase, Non-Receptor, 1 (TNK1) antibody
Background publications Azoitei, Brey, Busch et al.: "Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation." in: Oncogene, Vol. 26, Issue 45, pp. 6536-45, 2007 (PubMed).

Hoare, Hoare, Smith et al.: "Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling." in: Oncogene, Vol. 22, Issue 23, pp. 3562-77, 2003 (PubMed).