Tumor Necrosis Factor antibody (TNF)

Details for Product anti-TNF Antibody No. ABIN1109397, Supplier: Log in to see
Antigen
  • TNF
  • tnf
  • dif
  • tnfa
  • xtnf
  • TNF-a
  • tnfsf2
  • tnf-alpha
  • TNF-alpha
  • DIF
  • TNFA
  • TNFSF2
  • TNFalpha
  • Tnfa
  • Tnfsf1a
  • RATTNF
  • TNFa
  • cTNF
  • TNF-ALPHA
  • Cachectin
  • Tnf-alpha
  • tnfa-like
  • tumor necrosis factor (TNF superfamily, member 2)
  • tumor necrosis factor
  • tumour necrosis factor alpha-like
  • tumor necrosis factor alpha
  • lipopolysaccharide-induced TNF factor
  • tumor necrosis factor b (TNF superfamily, member 2)
  • TNF
  • tnf
  • tnf-alpha
  • LITAF
  • Tnf
  • tnfb
Alternatives
anti-Human Tumor Necrosis Factor antibody for Immunofluorescence (fixed cells)
Reactivity
Guinea Pig, Human, Mouse (Murine), Rhesus Monkey
1233
456
358
145
136
119
119
62
55
41
29
18
13
11
9
6
6
4
4
4
4
2
1
1
1
1
Host
Mouse
928
506
182
48
10
9
7
6
3
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This Tumor Necrosis Factor antibody is un-conjugated
167
100
74
50
32
30
28
27
26
25
25
25
25
25
24
24
24
23
13
9
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
870
852
612
310
282
229
211
190
137
118
98
74
29
27
26
22
20
16
14
8
7
6
6
6
6
5
5
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
Options
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Clone 52B83
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, guinea pig, rhesus monkey
Purification Protein G
Alternative Name Tumor Necrosis Factor (TNF-Alpha) (TNF Antibody Abstract)
Background TNF-alpha is a homotrimeric 17 kDa protein, that interacts with either one of the two types of TNF-receptors, termed I and II, leading to receptor cross-linking and signal transduction. The receptors differ strongly in their intra-cellular signaling pathways. TNF-alpha was originally described as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Furthermore, TNF-alpha is found to be a central mediator in many inflammatory and immunological processes. It can be induced by various products of micro-organisms and by various cytokines leading to expression of a wide variety of cytokines. The pro-inflammatory properties of TNF-alpha play a central role in several auto-immune diseases such as rheumatoid arthritis and inhibition by neutralizing molecules have been shown to be beneficial in patients.Synonyms: Cachectin, TNF, TNF-a, TNFA, TNFSF2, Tumor necrosis factor ligand superfamily member 2
UniProt P01375
Research Area Cytokines, Growth Factors, Receptors, Immunology, Inflammation, Cancer, Virology
Pathways NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Background publications Lee, Cho, Park: "Clinical and immunohistochemical characteristics of mucoceles." in: Annals of dermatology, Vol. 21, Issue 4, pp. 345-51, 2010 (PubMed).

van der Laan, de Leij, Buurman, Timens, ten Duis: "Tumor necrosis factor alpha (TNFalpha) in human skin: a comparison of different antibodies for immunohistochemistry." in: Archives of dermatological research, Vol. 293, Issue 5, pp. 226-32, 2001 (PubMed).

Gerspach, Götz, Zimmermann, Kolle, Böttinger, Grell: "Detection of membrane-bound tumor necrosis factor (TNF): an analysis of TNF-specific reagents." in: Microscopy research and technique, Vol. 50, Issue 3, pp. 243-50, 2000 (PubMed).

Bradding, Mediwake, Feather, Madden, Church, Holgate, Howarth: "TNF alpha is localized to nasal mucosal mast cells and is released in acute allergic rhinitis." in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Vol. 25, Issue 5, pp. 406-15, 1995 (PubMed).

Bradding, Roberts, Britten, Montefort, Djukanovic, Mueller, Heusser, Howarth, Holgate: "Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines." in: American journal of respiratory cell and molecular biology, Vol. 10, Issue 5, pp. 471-80, 1994 (PubMed).

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