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USP7 antibody (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated))

Details for Product anti-USP7 Antibody No. ABIN1109455, Supplier: Log in to see
Antigen
  • CG1490
  • Dmel\\CG1490
  • USP7
  • 2210010O09Rik
  • AA409944
  • AA617399
  • AU019296
  • AW548146
  • C80752
  • Hausp
  • HAUSP
  • TEF1
  • UBP
Reactivity
Human
131
24
23
5
4
3
3
1
1
1
1
1
1
1
Host
Mouse
95
36
1
Clonality (Clone)
Monoclonal ()
Conjugate
This USP7 antibody is un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
108
52
42
20
16
11
8
6
4
2
1
1
1
Supplier
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Clone 5F11
Isotype IgG1
Specificity Recognizes HAUSP
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name USP7 / HAUSP (USP7 Antibody Abstract)
Background USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)-dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.Synonyms: Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7
Molecular Weight 128 kDa
Gene ID 7874
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-USP7 antibody (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated)) (ABIN1109455) anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) antibody
Product cited in: Daubeuf, Singh, Tan et al.: "HSV ICP0 recruits USP7 to modulate TLR-mediated innate response." in: Blood, Vol. 113, Issue 14, pp. 3264-75, 2009 (PubMed).

Background publications Lu, Ma, Nguyen et al.: "The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop." in: Cancer cell, Vol. 12, Issue 4, pp. 342-54, 2007 (PubMed).

Becker, Marchenko, Maurice et al.: "Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma." in: Cell death and differentiation, Vol. 14, Issue 7, pp. 1350-60, 2007 (PubMed).