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WD Repeat Domain 5 (WDR5) antibody

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Synonyms zgc:56591, zgc:76895, wu:fk47f04, wdr5-a, MGC80538, wdr5-b, MGC81485, big-3, swd3, xwdr5, BIG-3, SWD3, 2410008O07Rik, AA408785, AA960360, Big, Big-3
(79), (17), (9)
(65), (15), (2), (1)
Clonality (Clone)
Monoclonal ()
(4), (3), (3), (2), (2), (2)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(73), (45), (13), (7), (5), (3), (3), (2), (1)
Pubmed 1 reference available
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Quantity 0.1 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Clone 7B11
Isotype IgG2b
Specificity Recognizes WDR5 / BIG3
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name WDR5 / BIG3 (WDR5 Antibody Abstract)
Background WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.Synonyms: BIG-3, BMP2-induced 3-kb gene protein, WD repeat-containing protein 5
Molecular Weight 36.6 kDa
Gene ID 11091
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Western Blotting (WB) image for anti-WD Repeat Domain 5 (WDR5) antibody (ABIN1109506) anti-WD Repeat Domain 5 (WDR5) antibody
Background publications Patel, Vought, Dharmarajan et al.: "A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex." in: The Journal of biological chemistry, Vol. 283, Issue 47, pp. 32162-75, 2008 (PubMed).

Catalog No. ABIN1109506
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