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ZBTB4 antibody

ZBTB4 Reactivity: Human WB, IHC (fro), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1109539
  • Target See all ZBTB4 Antibodies
    ZBTB4 (Zinc Finger and BTB Domain Containing 4 (ZBTB4))
    Reactivity
    • 34
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 34
    Rabbit
    Clonality
    • 34
    Polyclonal
    Conjugate
    • 10
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ZBTB4 antibody is un-conjugated
    Application
    • 34
    • 16
    • 13
    • 13
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts with 105 kDa ZBTB4 protein.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse.
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography on Protein A
    Immunogen
    Synthetic peptide derived from an internal domain of Human ZBTB4
    Top Product
    Discover our top product ZBTB4 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore in distilled water.
    Buffer
    0.1 M Tris, 0.1 M Glycine, 2 % Sucrose, None
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    ZBTB4 (Zinc Finger and BTB Domain Containing 4 (ZBTB4))
    Alternative Name
    ZBTB4 (ZBTB4 Products)
    Synonyms
    KAISO-L1 antibody, ZNF903 antibody, 2310026P19Rik antibody, 9230111I22Rik antibody, RP23-422L16.16 antibody, mKIAA1538 antibody, zinc finger and BTB domain containing 4 antibody, ZBTB4 antibody, Zbtb4 antibody
    Background
    The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions, this degradation increases with DNA damage.Synonyms: KAISO-L1, KAISO-like zinc finger protein 1, KIAA1538, Zinc finger and BTB domain-containing protein 4
    Gene ID
    57659
    NCBI Accession
    NP_001122305
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