ZIC2 antibody (C-Term)

Catalog No. ABIN1109557

Product Details anti-ZIC2 Antibody

Target: ZIC2

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Dog, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This ZIC2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-HSGLSSNFNE WY

Specificity: This antibody detects ZIC2 (C-term) and is not expected to cross-react with other ZIC proteins.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Canine (Dog), Bovine.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: Peptide with sequence from the C-Terminus of Human ZIC2 (NP_009060.2). Genename: ZIC2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ZIC2

Target: ZIC2

Alternative Name: ZIC2 (ZIC2 Products)

Synonyms: HPE5 antibody, Ku antibody, cb851 antibody, fb26a03 antibody, wu:fb26a03 antibody, zic2 antibody, zic2.1 antibody, hpe5 antibody, hm:zeh0655 antibody, id:ibd5017 antibody, zic2.2 antibody, zic2l antibody, Zic family member 2 antibody, zinc finger protein of the cerebellum 2 antibody, zic family member 2 (odd-paired homolog, Drosophila), a antibody, Zic family member 2 L homeolog antibody, zic family member 2 (odd-paired homolog, Drosophila) b antibody, ZIC2 antibody, Zic2 antibody, zic2a antibody, zic2.L antibody, zic2b antibody

Background: Zinc finger protein ZIC2 is a member of the GLI C2H2-type zinc-finger protein family. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Gene mutations cause holoprosencephaly type 5 in human brain and neural tube defects. Recent studies show that complete deficiency of the related murine ZIC2 transcription factor can also be a contributing factor to variable midline deficiencies, presenting during mid-gastrulation and similar forebrain anomalies.Synonyms: Zinc finger protein ZIC 2, Zinc finger protein of the cerebellum 2

Gene ID: 7546

NCBI Accession: NP_009060

Pathways: Tube Formation