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IGF1R antibody (Chain alpha)

IGF1R Reactivity: Human WB, FACS, IHC (p), Func Host: Mouse Monoclonal 1H7 unconjugated
Catalog No. ABIN111141
  • Target See all IGF1R Antibodies
    IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
    Binding Specificity
    • 26
    • 24
    • 24
    • 14
    • 13
    • 11
    • 10
    • 10
    • 10
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Chain alpha
    Reactivity
    • 193
    • 117
    • 98
    • 16
    • 7
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 181
    • 26
    • 2
    • 1
    Mouse
    Clonality
    • 183
    • 27
    Monoclonal
    Conjugate
    • 119
    • 10
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This IGF1R antibody is un-conjugated
    Application
    • 131
    • 73
    • 61
    • 60
    • 31
    • 30
    • 17
    • 13
    • 13
    • 10
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)
    Specificity
    Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting (Ref.1). Clone 1H7 is reported to partically block binding of IGF-I and IGF-II to CD221 (Ref.1)
    Purification
    Affinity Chromatography on Protein G
    Endotoxin Level
    Low Endotoxin
    Clone
    1H7
    Isotype
    IgG1
    Top Product
    Discover our top product IGF1R Primary Antibody
  • Application Notes
    Functional Assays. Western blotting. Immunohistochemistry on Paraffin Sections: 1/10-1/40. This product does not requireprotein digestion pre-treatment of paraffin sections. Use pancreas or placenta as histologypositive control tissue. Flow Cytometry Use 10 μL of 1/10 diluted antibody to label 10^6 cells in 100 μL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS without preservatives or stabilizers
    Preservative
    Without preservative
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
  • Hantel, Lewrick, Reincke, Süss, Beuschlein: "Liposomal doxorubicin-based treatment in a preclinical model of adrenocortical carcinoma." in: The Journal of endocrinology, Vol. 213, Issue 2, pp. 155-61, (2012) (PubMed).

    Hantel, Lewrick, Schneider, Zwermann, Perren, Reincke, Süss, Beuschlein: "Anti insulin-like growth factor I receptor immunoliposomes: a single formulation combining two anticancer treatments with enhanced therapeutic efficiency." in: The Journal of clinical endocrinology and metabolism, Vol. 95, Issue 2, pp. 943-52, (2010) (PubMed).

  • Target
    IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
    Alternative Name
    CD221 / IGF1R (IGF1R Products)
    Synonyms
    CMT2N antibody, CD221 antibody, IGFIR antibody, IGFR antibody, JTK13 antibody, IGFIRC antibody, IGFR1 antibody, IGF-1R antibody, IGF1R antibody, DKFZp469I0618 antibody, igf-1r antibody, xIGF-1R antibody, xIGFR antibody, xigf1r antibody, A330103N21Rik antibody, D930020L01 antibody, hyft antibody, igf-ir antibody, IGF-IR antibody, IGF-IRb antibody, wu:fb03h06 antibody, IGF-IRa antibody, sb:eu1090 antibody, wu:fi20b10 antibody, alanyl-tRNA synthetase antibody, insulin like growth factor 1 receptor antibody, insulin-like growth factor 1 receptor antibody, insulin-like growth factor 1 antibody, insulin-like growth factor I receptor antibody, insulin like growth factor 1 receptor S homeolog antibody, insulin-like growth factor 1b receptor antibody, insulin-like growth factor 1a receptor antibody, AARS antibody, IGF1R antibody, Igf1r antibody, igf1r antibody, Igf1 antibody, LOC780503 antibody, LOC100136427 antibody, igf1r.S antibody, igf1rb antibody, igf1ra antibody
    Background
    CD221, a 155 kD tyrosine kinase, is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin. The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins.Synonyms: IGF-I receptor, IGF1 Receptor, Insulin-like growth factor 1 receptor
    Gene ID
    3480
    NCBI Accession
    NP_000866
    UniProt
    P08069
    Pathways
    RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy
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